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Aortic Coarctation clinical trials

View clinical trials related to Aortic Coarctation.

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NCT ID: NCT06150560 Recruiting - High Blood Pressure Clinical Trials

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

VALUE
Start date: April 1, 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

NCT ID: NCT05880576 Enrolling by invitation - Clinical trials for Coarctation of the Aorta

The Arch Watch Study: An Integrated Evaluation of Hemodynamics in Infants With Suspected Coarctation of the Aorta

Start date: September 2023
Phase:
Study type: Observational

Unrecognized coarctation of the aorta (CoA) is a life-threatening component of congenital heart disease (CHD) in which narrowing of the aorta causes obstructed blood flow to the lower half of the body; it can occur in isolation or in combination with other defects. CoA is the type of CHD most likely to be missed by current newborn screening. An evolving coarctation (during closure of the ductus arteriosus) can be challenging to diagnose until often devastating end-organ injury manifests, even in the ICU setting. This study will evaluate currently used tools, such as four extremity blood pressures and pulse oximetry, and the investigators will test new tools - resonance Raman spectroscopy (RRS) and photoplethysmography analysis- to assess the adequacy of oxygen delivery in newborns who are at risk for aortic arch obstruction. The investigators hypothesize that combining an assessment of commonly used non-invasive monitoring tools, new components of these traditional tools, and RRS, will have improved sensitivity in detecting critical impairments to tissue oxygen delivery in newborns with suspected critical aortic arch obstruction.

NCT ID: NCT05842876 Recruiting - Clinical trials for Coarctation of Aorta

Happy Baby Hearts Study

Start date: April 19, 2023
Phase:
Study type: Observational

The goal of this observational study is to determine the feasibility of renal Near Infrared Spectroscopy (NIRS) monitoring in the newborn nursery for newborns at low risk of coarctation of the aorta (CoA). The main questions it aims to answer are: - whether continuous renal NIRS monitoring is feasible; - whether NIRS monitoring results in higher nursing and parent/caregiver satisfaction than current standard monitoring; and, - whether participants who develop CoA will spend a smaller proportion of time within the normal range than patients who do not have CoA. Participants will be observed through continuous renal oxygenation monitoring with NIRS.

NCT ID: NCT05475561 Completed - Clinical trials for Mitral Regurgitation

Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery

Start date: May 25, 2022
Phase: Phase 2
Study type: Interventional

The current study is designed to compare the perioperative analgesic efficacy of Erector spinae plane block (ESPB) and Pecto-intercostal-fascial plane block (PIFB) in adults undergoing cardiac surgery via median sternotomy. The primary outcome measure will be the analgesic effectiveness of both blocks in median sternotomy pain, while the secondary outcome measures will be time to extubation, and length of intensive care unit stay.

NCT ID: NCT05405790 Active, not recruiting - Aortic Dissection Clinical Trials

Antibiotic Prophylaxis for TEVAR

Start date: January 1, 2022
Phase:
Study type: Observational

The infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of care. Because of the potentially fatal consequences of a stent graft infection in the thoracic aorta, the investigators tend to prescribe antibiotic prophylaxis for at least three days. In this study, the investigators are going to collect data on patients receiving TEVAR in the past five years and provide the following information: a. the infection rate (MAGIC classification), b. the rate of fever, c. the results of the lab tests, such as the WBC count and C-reaction protein. d. risk factors associated with infection and fever.

NCT ID: NCT05362721 Recruiting - Clinical trials for Coarctation of Aorta

PV Loop & Coarctation Study

Start date: June 4, 2019
Phase:
Study type: Observational

Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.

NCT ID: NCT05203874 Recruiting - Clinical trials for Congenital Heart Disease

Contribution of Multimodal Imaging in Early Coarctation

CT-COARCT-PED
Start date: January 1, 2022
Phase:
Study type: Observational

The CT-Coarct-PED study is a multicentred observational study aiming to describe the population of early coarctation during the last 10 years in South of France. The secondary objective is to assess the importance of cross-sectional imaging in the surgical management of aortic coarctation in the first year of life

NCT ID: NCT05132946 Recruiting - Anesthesia Clinical Trials

Ultrasound-guided Erector Spinae Plane Block: A Comparative Study to Assess Its Analgesic Efficacy in Pediatric Patients Undergoing Aortic Coarctation Repair

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

The study will include 40 patients who fulfil all the points in the inclusion and exclusion criteria will be randomized into two equal groups, each consisting of 20 patients, namely group (B) and group (C). - Group (B): will receive erector spinae plane block. - Group (C): will not receive any block. Postoperative pain score will be assessed using the FLACC scale or Face, Legs, Activity, Cry, Consolability scale immediately after extubation and at 1, 2, 4, 6, 8, 12, 18, and 24 hours. Routine postoperative analgesia in the form of intravenous paracetamol 7.5 mg/kg/6 hours will be given to all patients (the first dose is given after skin closure). Rescue analgesia in the form of 1 ug/kg fentanyl intravenously for patients if FLACC scale > 4, and the time for the first rescue analgesic administration will be recorded.

NCT ID: NCT05086016 Active, not recruiting - Clinical trials for Pulmonary Artery Stenosis

Growth Trial: Study of the Renata Minima Stent

Start date: January 14, 2021
Phase: N/A
Study type: Interventional

The objective of the clinical investigation is to access clinical safety and effectiveness of the Minima Stent in neonates, infants, and young children requiring intervention for common congenital vascular stenosis (i.e., coarctation of the aorta and/or pulmonary artery stenosis) who are indicated for treatment.

NCT ID: NCT05022836 Completed - Blood Pressure Clinical Trials

Four-limb Blood Pressures in Infants With High Risk of Congenital Malformation of Aorta

Start date: January 1, 2013
Phase:
Study type: Observational

Pulse oximetry screening (POS) for critical congenital heart diseases (CCHD) could identify 90% of these infants. However, this approach is not designed to detect cardiac defects without hypoxemia, especially congenital malformations of aorta (CMoA). More than 60% of CMoA was late diagnosed. Infants with CMoA were supposed to present with blood pressure (BP) gradient between four limbs. But a large sample size retrospective study of four-limb BP screening showed a negative result. The possible reason is that this study ran in population with a very low risk of CMoA. Whether four-limb BPs measurement could be used in infants with high risk of congenital malformation of aorta is still to be determined. The investigators retrospectively collected four-limb BPs, which was prospectively measured, in infants with high risk of CMoA. These data were divided into two groups, the discovery group and the validation group. The best cutoff of four-limb BP gradient was generated by Youden Index. The BP gradients by age were analyzed. Pre-operative hypotension and post-operative hypertension were also analyzed.