Anxiety Clinical Trial
Official title:
MIDAZOLAM EFFECTIVENESS TO THE SEDATION IN FLEXIBLE BRONCHOSCOPY. A RANDOMIZED STUDY
The Flexible Bronchoscopy (FB) is a diagnostic and therapeutic procedure which is not
usually tolerated by the patient. This makes the examination more difficult and a repetition
of the examination, if necessary, resulting in a lower diagnostic performance.
Furthermore, there is nowadays little information with a highly obvious level about the
relationship between sedation and the patient´s satisfaction with the FB.
Midazolam is one of the most commonly used sedatives at the beginning for its rapid onset
property and brief duration of action with sedatives, anxiolytics and amnesia properties.
The principal aim of our study is to analyse if the use of a local anaesthetic with
midazolam whilst performing an FB improves the quality of examination in terms of tolerance
for the patient. It would also be of interest to know if there is an improvement in the
acceptance of a second or further FB and if this improves the satisfaction of the
Bronchoscopist as far as the examination performed is concerned.
PATIENTS AND METHODS:
A randomized, prospective study has been carried out; double blind and controlled with
placebo to be treated with midazolam. This included 152 patients, randomized into two
groups: Group A - 79(51.9%) patients which received midazolam before the FB, and Group B -
(49.1%) patients which received placebo. The patients were given a questionaire of 13
questions about different aspects of perception of the procedure after the respiratory
endoscopy and another was given to the Bronchoscopist.
RESULTS:
Both groups started off with a similar assessment of fear and nervousness before the FB.
Nevertheless, Group A gave a much higher score than Group B referring to variables related
to symptoms and feeling. The patients´ cooperation was assessed by the Bronchoscopist in a
similar way in both groups, although the length of the procedure and difficulty was higher
in the group treated with placebo (Group B).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)
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