Anxiety Disorders Clinical Trial
Official title:
Dynamic Treatment vs. CBT for Panic Disorder
Verified date | November 2022 |
Source | Weill Medical College of Cornell University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will determine the relative effectiveness of three psychotherapies in treating people with a panic disorder.
Status | Completed |
Enrollment | 201 |
Est. completion date | September 2012 |
Est. primary completion date | March 2012 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Meets DSM-IV diagnosis criteria for primary PD with or without agoraphobia - History of at least one spontaneous panic attack per week within the month prior to study entry Exclusion Criteria: - Active substance dependence within 6 months prior to study entry - Lifetime history of any psychotic disorder, including bipolar disorder - Acutely suicidal |
Country | Name | City | State |
---|---|---|---|
United States | Weill Medical College of Cornell University | New York | New York |
United States | University of Pennsylvania School of Medicine | Philadelphia | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Weill Medical College of Cornell University | National Institute of Mental Health (NIMH) |
United States,
Milrod B, Chambless DL, Gallop R, Busch FN, Schwalberg M, McCarthy KS, Gross C, Sharpless BA, Leon AC, Barber JP. Psychotherapies for Panic Disorder: A Tale of Two Sites. J Clin Psychiatry. 2016 Jul;77(7):927-35. doi: 10.4088/JCP.14m09507. — View Citation
Milrod B, Leon AC, Busch F, Rudden M, Schwalberg M, Clarkin J, Aronson A, Singer M, Turchin W, Klass ET, Graf E, Teres JJ, Shear MK. A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder. Am J Psychiatry. 2007 Feb;164(2):265-72. doi: 10.1176/ajp.2007.164.2.265. Erratum In: Am J Psychiatry. 2007 Jul;164(7):1123. Am J Psychiatry. 2007 Mar;164(3):529. — View Citation
Milrod BL, Leon AC, Barber JP, Markowitz JC, Graf E. Do comorbid personality disorders moderate panic-focused psychotherapy? An exploratory examination of the American Psychiatric Association practice guideline. J Clin Psychiatry. 2007 Jun;68(6):885-91. doi: 10.4088/jcp.v68n0610. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Panic Disorder Severity Scale | A composite score of panic severity. High value = 28, lowest value =0. Higher=worse | 12 weeks | |
Secondary | Sheehan Disability Scale | Level of psychosocial functional impairment. highest value=30, lowest value =0, higher numbers indicate greater dysfunction | 12 weeks | |
Secondary | Clinical Global Impressions Scale | Clinical assessment of severity of impairment. Minimum value=1, maximum value =6; high scores worse | 12 weeks | |
Secondary | Hamilton Depression Rating Scale | Level of state depression. scale 0-81, 0 symptom free, 81 worst severity | 12 weeks | |
Secondary | Hamilton Anxiety Rating Scale | level of state anxiety. 0=symptom free, 56 most severe | 12 weeks | |
Secondary | Anxiety Disorder Sensitivity Index | Anxiety disorder sensitivity index measures Sensitivity to physical symptoms of anxiety (scores range from 0-64). 0= no anxiety, 64 =maximum anxiety | 12 weeks | |
Secondary | Brief Body Sensitivity Interpretation Questionnaire (BBSIQ) | The BBSIQ measures how physically sensitive the person is to physical symptoms of anxiety; (scores range 0-63) 0= no anxiety; 63= highest levels of physical anxiety | 12 weeks | |
Secondary | Panic-Specific Reflective Function | Ability to reflect on the emotional meaning of panic symptoms. scored -1 to 9, high numbers better | 12 weeks |
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