Anxiety Disorders Clinical Trial
Official title:
Child/Adolescent Anxiety Multimodal Treatment Study
This randomized, controlled trial compared the efficacy of the medication sertraline (Zoloft®), cognitive-behavioral therapy, the combination of these treatments, and placebo for youth with anxiety disorders.
Anxiety disorders are among the most common conditions affecting children and adolescents.
These disorders impair school, social, and family functioning. When left untreated, they also
put children at risk for major depression and substance abuse in late adolescence and
adulthood. Previous studies demonstrated the efficacy of cognitive behavioral therapy and
selective serotonin-reuptake inhibitors for the treatment of child anxiety disorders. This
study is testing the relative and combined efficacy of cognitive behavioral therapy and
selective serotonin reuptake inhibitors as compared to each other and pill placebo.
During Phase I of this two-phase study, 488 participants were randomly assigned to receive
sertraline (Zoloft), cognitive behavioral therapy, a combination of these treatments, or a
placebo for 12 weeks. Phase II involved a 6-month maintenance period for participants.
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