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Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss

Antiphospholipid Syndrome Clinical Trial

Official title:
Randomised Controlled Trial of Low Dose Steroid +Aspirin +Heparin Versus Aspirin+Heparin Amongst Pregnant Women With APS

Clinical Trial Summary

Does the addition of steroids during the first trimester to the standard aspirin + heparin treatment reduce the miscarriage rates in women with antiphospholipid antibodies and recurrent first trimester miscarriage in those who had an unsuccessful pregnancy with aspirin + heparin?

Clinical Trial Description

Over the last decade, the APS has emerged as most important treatable cause of recurrent miscarriages. The pathogenesis of fetal loss in this condition is still remains obscure. Despite the success of aspirin + heparin treatment, some pregnant women with APS repeatedly miscarry even on treatment. The trial is designed to determine if addition of steroids has an success in these women. This is in view of recent in vitro data from our unit reporting that there is an increase decidual cytokine response in APS positive women. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00180778
Study type Interventional
Source Imperial College London
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date October 2005
Completion date October 2005
View Details
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