Antiphospholipid Syndrome Clinical Trial
Official title:
Constitution d'Une Collection d'Echantillons Biologiques Associee a Une Base de Donnees de Patients Possedant Des Anticorps Antiphospholipides
To constitute a registry of antiphospholipid antibodies positive-patients
An international web-based application, the REDCap (Research Electronic Data Capture), captures data on patient demographics, aPL-related clinical and laboratory characteristics, and medications. The inclusion criteria are: a) age between 18 and 60 years; and b) persistent (at least 12 weeks apart) aPL-positivity within 12 months prior to screening; positivity is defined as anticardiolipin antibodies (aCL) IgG/M/A (> 40 GPL/MPL/APL, medium-to-high titer, and/or greater than the 99th percentile), anti-β2-glycoprotein-I (aβ2GPI) IgG/M/A (> 40 units, medium-to-high titer), positive lupus anticoagulant (LA) test based on International Society on Thrombosis and Hemostasis and other current guidelines. Patients are followed every 12 ± 3 months with clinical data and blood collection. Blood drawn is done at inclusion and every year. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01475149 -
Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE)
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N/A | |
| Completed |
NCT00537290 -
A Pilot Study of Rituximab for the Anticoagulation Resistant Manifestations of Antiphospholipid Syndrome
|
Phase 2 | |
| Recruiting |
NCT00616317 -
Register for Pediatric Patients With Antiphospholipid Syndrome (APS): European Project Extended Internationally Study
|
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| Recruiting |
NCT00198068 -
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
|
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| Completed |
NCT00180817 -
Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies.
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| Completed |
NCT03682419 -
Evaluation of Precision and Accuracy of INR Measurements in a Point of Care Device (OPTIMAL)
|
N/A | |
| Not yet recruiting |
NCT03303508 -
Measurement of Anti-dsDNA by Both CLIFT & ELISA
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N/A | |
| Recruiting |
NCT04262492 -
International Registry of Thrombotic APS Patients Treated With Direct Oral Anticoagulants
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| Withdrawn |
NCT00180778 -
Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss
|
Phase 1/Phase 2 | |
| Enrolling by invitation |
NCT05583305 -
Prevalence and Etiologies of Intracranial Stenosis in Patients With Antiphospholipid Syndrome
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| Recruiting |
NCT05644210 -
Telitacicept Followed With Rituximab Therapy on APS Secondary to SLE
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| Recruiting |
NCT02303171 -
Use of Warfarin After the First Trimester in Pregnant Women With APS
|
Phase 4 | |
| Not yet recruiting |
NCT06420154 -
The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refractory Autoimmune Diseases
|
Early Phase 1 | |
| Completed |
NCT00674297 -
Effects of Fluvastatin on Proinflammatory and Prothrombotic Markers in Antiphospholipid Syndrome Patients
|
Phase 2 | |
| Recruiting |
NCT05859997 -
Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases
|
N/A | |
| Recruiting |
NCT06373003 -
Negative Antiphospholipid Syndrome: a Multicentric Study
|
||
| Recruiting |
NCT06373926 -
Evaluation of Cell Membrane Expression of Annexin A2 on Monocytes by Flow Cytometry in Primary Antiphospholipid Syndrome
|
N/A | |
| Recruiting |
NCT01818505 -
The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome
|
N/A | |
| Completed |
NCT00878137 -
Reliability of Point-of-care INR Measurements in Patients With Antiphospholipid-antibody Syndrome Treated With Warfarin
|
N/A | |
| Completed |
NCT01104337 -
Drug Interaction Between Paracetamol and Warfarin
|
Phase 4 |