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Retinoids in ANCA Small Vessel Vasculitis: Silencing Autoantigens

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Clinical Trial

Official title:
Retinoids in ANCA Small Vessel Vasculitis: Silencing Autoantigens

Clinical Trial Summary

The purpose of this research study is to learn if adding all-trans retinoic acid (tretinoin) to conventional treatment of Anti- Neutrophil Cytoplasmic Autoantibodies (ANCA) vasculitis can decrease the level of disease activity.

Clinical Trial Description

Neutrophils are white blood cells that are the target of the ANCA antibodies. T cells are white blood cells that are involved in regulating the immune system. Laboratory research studies suggest that all-trans retinoic acid (tretinoin) can affect the neutrophils and the T lymphocytes in such a way that could decrease the abnormal immune response directed against the body own neutrophils. ;

Study Design

Related Conditions & MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
  • Vasculitis
Clinical Trial Details
NCT number NCT01275274
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Withdrawn
Phase Phase 2
Start date January 2012
Completion date December 2013
View Details
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