Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

Anesthesia Clinical Trial

Official title:

The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05628935
• Other study ID #: 2020-22/17
• Status: Completed
• Start date: January 1, 2018
• Est. completion date: November 1, 2021

Study information

• Verified date: November 2022
• Source: Zonguldak Bulent Ecevit University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1
• Est. completion date: November 1, 2021
• Est. primary completion date: November 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Underwent forearm surgery
• Between aged 18-70
• Under general anesthesia or peripheral nerve block

Exclusion Criteria:

• acute infection
• morbid obesity
• chronic treatment with steroids or immunosuppressants
• recently received chemotherapy
• hepatic and renal dysfunction;
• chronic alcohol abusers
• Multiple trauma
• Patients with missing data in their files

Related Conditions & MeSH terms

• Anesthesia
• Inflammation

Intervention

Procedure:
• peripheral nerve block
local anesthetic application to the brachial plexus

Locations

Country	Name	City	State
Turkey	Zonguldak Bülent Ecevit University Medicine Faculty	Zonguldak	Kozlu

Sponsors (1)

Lead Sponsor	Collaborator
Zonguldak Bulent Ecevit University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neutrophil/lymphocyte ratio	Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block	up to 24 hours after surgery
Secondary	Platelet/lymphocyte ratio	Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block	up to 24 hours after surgery
Secondary	Mean Platelet Volume	Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block	up to 24 hours after surgery