Dexmedetomine vs Dexamethasone in TAB Block for Abdominal Surgries

Anesthesia Clinical Trial

Official title:

A Comparative Study Between the Use of Dexmedetomidine Versus Dexamethasone as Adjuvant to Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block for Post-operative Pain Relief in Patients Undergoing Lower Open Abdominal Surgeries

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05323565
• Other study ID #: FMASU M D 184/2020
• Status: Active, not recruiting
• Phase: Phase 4
• Start date: April 1, 2022
• Est. completion date: July 5, 2022

Study information

• Verified date: April 2022
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Randomized controlled clinical Trial to compare the efficacy and duration of postoperative analgesia achieved after adding dexmedetomidine or dexamethasone to bupivacaine in TAP block for lower open abdominal surgeries.

Description:

A Comparative study between the use of dexmedetomidine versus dexamethasone as adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block for post-operative pain relief in patients undergoing lower open abdominal surgeries

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 45
• Est. completion date: July 5, 2022
• Est. primary completion date: July 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

Adult patients, Age 20-60 years. Elective operation under general anesthesia. Physical Status: ASA I and II Patients. Body mass index 25-35 kg/m2.

Exclusion Criteria:

• Infection at site of injection.
• Patient refusal.
• Psychiatric or physical illness that lead to inability to cooperate, speak or read.
• Abdominal operations under spinal anesthesia.
• History or evidence of coagulopathy.
• Known allergies to drugs used .
• Preexisting neurological disorders.

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Dexmedetomidine
adjuvants to 0.25 bupivacaine in TAB block.

Locations

Country	Name	City	State
Egypt	Ain Shams University, Faculty of medicine	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	1st time for rescue analgesia	Time to first analgesia requirment(starting from drug injection)	first 24 hours post-operatively
Secondary	Pain score- Visual Analogue Score (VAS)	It ranges from 0 indicating no pain till 10 indicating severe intolerable pain with variable degrees of ascending pain in between] was assessed at 0 min (AT PACU), 2hr,6 hr, 12 hr, 18 hr, and 24 hr postoperatively.	First 24 hours post-operatively.