Anesthesia, Local Clinical Trial
Official title:
Does Perineural Dexamethasone Increase the Duration of an Ulnar Nerve Block When Controlling for Systemic Effects? A Randomised, Blinded, Placebo-controlled, Paired, Non-inferiority Trial in Healthy Volunteers.
Investigators will assess if perineural dexamethasone can increase the duration of an ulnar nerve block when controlling for systemic effects in healthy volunteers.
Healthy volunteers will have bilateral ulnar nerve blocks performed with bupivacaine on two different days with a minimum of 14 days wash-out. On one day, the participants will also receive dexamethasone in one arm and placebo in the other. On the other day, the participants will also receive placebo in one arm and lidocaine in the other. By this using this design, the investigators will be able to assess if perineural dexamethasone can increase the duration of an ulnar nerve block when controlling for the systemic effects. Furthermore, to ensure blinding, the investigators have also incorporated the lidocaine group which also allows for the assessment of the effects of adding lidocaine to a peripheral nerve block with bupivacaine. The order of which the participant will receive dexamethasone and lidocaine will be random. It will also be random in which arm the participant receives dexamethasone and lidocaine. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03663478 -
Continuous TQL Block for Elective Cesarean Section
|
Phase 4 | |
| Completed |
NCT04513652 -
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
|
Phase 3 | |
| Completed |
NCT05464862 -
The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers
|
Phase 4 | |
| Completed |
NCT04690647 -
The Efficacy of Suprainguinal Fascia Iliaca Compartment Block for Analgesia After Elective Total Hip Replacement.
|
N/A | |
| Completed |
NCT03245359 -
Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks
|
N/A | |
| Recruiting |
NCT06028126 -
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
|
N/A | |
| Not yet recruiting |
NCT05815563 -
Validation of Peripheral Perfusion Index in Predicting Successful Supraclavicular Brachial Plexus Block in Pediatrics
|
||
| Completed |
NCT01418690 -
Changes in Tissue Oxygenation Following Regional Anesthesia
|
N/A | |
| Suspended |
NCT03291691 -
Protective Nerve Stimulation in Regional Anesthesia
|
||
| Not yet recruiting |
NCT03545516 -
Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery
|
Phase 2 | |
| Not yet recruiting |
NCT05038007 -
Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades
|
Phase 2 | |
| Terminated |
NCT03672500 -
Perineal Local Infiltration Study
|
N/A | |
| Enrolling by invitation |
NCT06057090 -
Do Therapy Dogs Improve Behavior and Reduce Anxiety in Pediatric Dental Patients?
|
N/A | |
| Recruiting |
NCT05415865 -
The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder
|
Phase 3 | |
| Recruiting |
NCT06011005 -
Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel.
|
N/A | |
| Completed |
NCT04536311 -
Surgical Stabilization of Rib Fractures While Awake or Under Appropriate Sedation by Paravertebral Block
|
N/A | |
| Completed |
NCT03600454 -
The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response
|
N/A | |
| Recruiting |
NCT03159338 -
Platelet-rich Fibrin on Nerve Regeneration After Bilateral Sagittal Split Osteotomy
|
N/A | |
| Completed |
NCT02966067 -
A Split Mouth Trial to Compare Microneedles vs. Standard Needles in Dental Anaesthetic Delivery
|
N/A | |
| Completed |
NCT03305666 -
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
|
Phase 4 |