Anesthesia, General Clinical Trial
Official title:
The Effect of Frontal Electromyogram (F-EMG) Activity on the Entropy Index Behavior During General Anesthesia
This study evaluates the effect of frontal EMG activity on Entropy index in burst suppression level of propofol anesthesia and surgery
This is an academic observational study, where EEG is recorded during conventional
propofol-remifentanil-rocuronium anesthesia and surgery in informed, consenting adults,
during their surgical operations in Tampere University Hospital. The patients will be
informed about the possibility to participate during their preoperative visit, and the
approval will be asked on arrival in the day of surgery, before premedication.
The course of anesthesia will not be changed. The monitoring of the anesthetic state will be
conventional: Heart rate, blood pressure, oxygen saturation of blood, Entropy Index,
neuromuscular blockade will be monitored, as is the case in all surgical patients under
general anesthesia in Tampere University Hospital. Any further monitoring will apply
depending on the specific needs of the particular patient. Entropy Index data, EEG data and
neuromuscular blockade data will be recorded on computer and analyzed later at GE Healthcare
R&D Department, Helsinki, Finland, by Dr. Mika Särkelä. All data leaving Tampere University
Hospital will be anonymized.
Anesthetic induction will be given in a conventional way (intravenous propofol and
remifentanil, followed by intravenous rocuronium). EEG waveform is monitored with Entropy
module. Neuromuscular blockade will be monitored with EMG-NMT module (GE-Healthcare). The
data collection (Entropy, EEG, neuromuscular transmission (NMT) data) will last at least
until skin incision.
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