Anemia Clinical Trial
Official title:
Health Economics of the Use of Ferrous Iron Salts in Primary Care in the UK.
Iron deficiency anaemia (IDA) affects approximately 4.7 million of people in the UK, with
children and pre-menopausal women being at higher risk (1). Each year more than 6.8 million
prescriptions for oral iron are filled in England alone (NHS Information Centre data).
However, gastrointestinal symptoms limit adherence in 10-30% of otherwise healthy patients
(2-4) and in up to 50% of patients with gastrointestinal disorders (5). Simple ferrous iron
salts constitute the vast majority of currently prescribed oral iron because these are cheap
and well absorbed. However, they are also poorly tolerated and thus, we believe, are
expensive to the NHS.
Funded by the Medical Research Council, we have developed an alternative oral iron
supplement, that we name IHAT (iron hydroxide adipate tartrate), as an efficacious therapy
for IDA with minimal side-effects.
In the study proposed here we aim to assess the total health cost associated with current
oral iron supplements and, hence, define the clinical unmet need for alternative treatments.
We will use Clinical Practice Research Datalink (CPRD) GOLD data to (i) estimate the pattern
of prescribing to oral iron in primary care in the general population and (ii) develop a
health economics model in pre-menopausal women. These data will provide evidence for the
total health system costs associated with current oral iron treatment. Furthermore, this
study will provide data from which the cost-effectiveness and total health system costs of
alternative effective and treatments with minimal side-effects could be estimated.
Our research objective is to gather evidence for the unmet clinical need for safe,
low-side-effect oral iron in the UK.
To achieve this objective we aim to determine:
1. Pattern of prescribing to oral iron in primary care in GP practices in England: estimate
prescription rates, efficacy and intolerance of treatment with all forms of currently
prescribed oral iron.
2. Health economics of the use of ferrous iron salts in primary care: estimate patterns of
individual response to treatment; determine the costs of ferrous iron (sulphate,
fumarate and gluconate) therapy in pre-menopausal women in primary care, and develop a
cost-effectiveness model for alternative treatments with minimal side-effects.
;
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