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NCT01553552 Clinical Trial

Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal

Anemia Clinical Trial

— SchistoVAN  

Official title:
Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01553552
Other study ID # EPLS11-MS
Secondary ID
Status Completed
Phase N/A
First received March 12, 2012
Last updated March 13, 2012
Start date October 2011
Est. completion date October 2011

Study information
Verified date March 2012
Source Biomedical Research Center EPLS
Contact n/a
Is FDA regulated No
Health authority Senegal: Ministere de la sante
Study type Observational

Clinical Trial Summary

SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.

Description:

SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.

The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.

Aims of the study:

To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.

To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)

To study prevalence of intestinal parasites such as Blastocystis hominis

Recruitment information / eligibility
Status Completed
Enrollment 99
Est. completion date October 2011
Est. primary completion date October 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 6 Years to 10 Years
Eligibility Inclusion Criteria:

- Members of AnoPalAnoVac cohort

- Age: between 6 and 10 years

Exclusion Criteria:

- body temperature > 38.5 ºC

- malaria episode

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Senegal Biomedical Research Center EPLS Saint-Louis SL

Sponsors (7)
Lead Sponsor Collaborator
Biomedical Research Center EPLS Centre d'Infection et d'Immunité de Lille, France: Centre National de la Recherche Scientifique, Institut National de la Santé Et de la Recherche Médicale, France, Institut Pasteur de Lille, Région Nord-Pas de Calais, France, University of Lille Nord de France

Country where clinical trial is conducted

Senegal, 

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