Anemia Clinical Trial
Official title:
Non- Invasive Measurement of the Absolute Hemoglobin Value in the Retinal Arteries of Anemic and Healthy Subjects Using a New Approach
The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries.
To our knowledge no tool exists that allows for direct collection of hemoglobin data in the
eye. In many eye diseases (especially diabetic and hypertensive retinopathy as well as in
retinal vessel occlusions) retinal circulation is modified. Knowing hemoglobin concentration
on the site of the pathology will give us further information about the pathogenesis of this
diseases and may provide a new possibility in therapy.
The purpose of this study is to test a new non-invasive tool to measure hemoglobin in
retinal arteries. Healthy volunteers from the eye clinic and pregnant otherwise healthy
patients of the gynecological department of the Triemli Hospital, Zurich, as well as anemic
gynecological patients that show up for a check-up are included.
Hemoglobin will be quantified by a blood draw of a cubital vein. Using a Fundus Camera
(Nidek AFC-230) pictures of the fundus will be taken from each study patient. Afterwards the
study investigator selects a retinal artery of interest which will be used for measuring the
hemoglobin concentration. Intensity of the green channel of the camera chip is determined
with the aid of the law of Lambert-Beer.
Absolute Hemoglobin concentration is calculated in relation to the vessel volume.
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