Anemia Clinical Trial
Official title:
Transfusions and Nitric Oxide Level in Preterm Infants
The purpose of this study is to better understand S-nitrosohemeglobin (SNO-Hb) in transfused
blood of extremely preterm infants. The long term goal of the project is to identify
variation in the SNO-Hb between packed red blood cell units, and between and among individual
preterm infants pre and post-transfusion. Duke investigators are developing methods to
replenish SNO-Hb, which, if successful, would improve RBC deformation in addition to
providing a vasodilatory stimulation to hypoxic tissue, and lead to a randomized clinical
trial testing treated vs. untreated RBC transfusions in extremely premature infants.
AIM 1. Measure the Total Hemoglobin (Hb)-bound nitric oxide (NO), Hb [Fe] NO, SNO-Hb (a
calculated value = (total Hb-NO - Hb [Fe] NO) in blood to be transfused in extremely preterm
babies, and in samples pre and post- transfusion from the babies.
Hypothesis 1: Measures of NO and SNO-Hb will be low in blood used for transfusion in preterm
infants and will be decreased in the post-transfusion samples from the infants compared with
the pre-transfusion samples.
AIM 2. Collect clinical data about study participants, including oxygen saturation and
measures of perfusion pre and post-transfusion.
Hypothesis 2: Measures of perfusion will be reduced by 20% post-transfusion in extremely
preterm infants.
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