Anemia Clinical Trial
Official title:
Effects of Anemia Correction on Vascular Function, Endothelial Cell Markers and Monocyte Apoptosis in Renal Transplant Recipients
Verified date | May 2008 |
Source | University Hospital Muenster |
Contact | n/a |
Is FDA regulated | No |
Health authority | Germany: Ethics Commission |
Study type | Interventional |
Correction of anaemia in renal transplant recipients by parenteral application of
recombinant erythropoietin and if necessary iron will improve large artery function
(endothelial function and elasticity), as assessed by ultrasound techniques and applanation
tonometry.
The changes in large artery function will be reflected by changes in serological markers of
endothelial function and oxidative stress and by changes in monocyte function and apoptosis.
There are gender differences in the responses of vascular function to correction of anemia.
Besides improvement of large artery function, correction of anemia will also affect
parameters of graft function, i.e. glomerular and tubular proteinuria.
Status | Completed |
Enrollment | 60 |
Est. completion date | January 2010 |
Est. primary completion date | January 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: kidney transplant recipient stable kidney function Hb between 10mg/ml and 10.5mg/ml Exclusion Criteria: acute rejection Hb above 12.0mg/dl |
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Germany | UKM | Münster | NRW |
Lead Sponsor | Collaborator |
---|---|
University Hospital Muenster | Amgen |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Vessel wall stiffness | |||
Secondary | expression of endothelial cell markers |
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