The Utility of Platelet Rich Plasma in Hair Loss

Androgenetic Alopecia Clinical Trial

Official title:

The Utility of Platelet Rich Plasma in Hair Loss

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03376581
• Other study ID #: 20163239
• Status: Completed
• Phase: Early Phase 1
• Start date: November 28, 2017
• Est. completion date: February 20, 2019

Study information

• Verified date: February 2024
• Source: University of California, Irvine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Platelet rich plasma (PRP) is an autologous preparation of human plasma with high concentration of platelets. Platelets release numerous growth factors, which stimulate cell proliferation and differentiation. The purpose of this research is to investigate the potential of PRP injection for treatment of hair loss. Clinical outcomes will be assessed by noninvasive techniques including dermoscopy, multiphoton microscopy, optical coherence tomography, optical Doppler tomography and multispectral imaging.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: February 20, 2019
• Est. primary completion date: February 20, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 95 Years

Eligibility

Inclusion Criteria:

• Over 18 years of age
• Ability to understand and carry out instructions
• Diagnosed with alopecia

Exclusion Criteria:

• Inability to understand and.or carry out instructions
• Pregnant women
• Use of any topical medication (such as minoxidil or any other solution for hair growth), oral medication (finasteride, dutasteride, or antiandrogens), laser therapy, or chemotherapy, within the preceding 4 weeks.
• Personal medical history of bleeding disorders
• Personal medical history of platelet dysfunction syndrome
• Anti-coagulation therapy or nonsteroidal anti-inflammatory drugs in the last 1 week.

Related Conditions & MeSH terms

• Alopecia
• Androgenetic Alopecia

Intervention

Procedure:
• Platelet rich plasma
Blood drawn from each participant will be spun down to separate platelets. Platelets will be injected into that patient's scalp.

Locations

Country	Name	City	State
United States	University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall	Irvine	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Irvine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hair density to measure the efficacy of treatment		6 months
Secondary	Hair count (number of hairs/0.65 cm2)		6 months
Secondary	Terminal hair density		6 months
Secondary	Anagen hair percentage		6 months
Secondary	Telogen hair percentage		6 months
Secondary	Anagen/telogen ratio		After 3 and 6 months
Secondary	Changes in hair structure, diameter, and blood flow	As measured by optical coherence tomography	6 months