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ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of Labor Analgesia

Analgesia Clinical Trial

Official title:
ED90 of Epidural Bupivacaine for the Initiation of Labor Analgesia: A Randomized Biased Coin Sequential Allocation Trial With a Lidocaine Test Dose

Clinical Trial Summary

To estimate the dose of bupivacaine required to achieve initial effective comfort in 90% of patients (ED90) via the epidural (DPE or EPL) technique in women undergoing labor after receiving a lidocaine "test dose"

Clinical Trial Description

The primary objective of our study is to use a biased coin up-down allocation methodology to estimate the dose of bupivacaine required to achieve initial effective comfort in 90% of patients (ED90) via the epidural (DPE or EPL) technique in women undergoing labor induction or augmentation; we hypothesize that we will be able to determine the ED90 of bupivacaine for each technique with adequate precision to inform the optimal doses. We will be conducting this study in women who receive a prior lidocaine "test dose" used in standard clinical practice ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05543694
Study type Interventional
Source Brigham and Women's Hospital
Contact Lawrence C Tsen, MD
Phone 617-732-8216
Email ltsen@bwh.harvard.edu
Status Recruiting
Phase Phase 4
Start date October 1, 2022
Completion date October 1, 2024
View Details
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