Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to determine if different reinforcement procedures (i.e., schedules) produce different patterns of long-term abstinence from methamphetamine. We anticipate that the three contingency management conditions will promote longer periods of abstinence in the year following treatment relative to the standard control group. Furthermore, we predict that the intermittent reinforcement procedures will produce longer periods of continued abstinence (i.e., long-term behavior change) in the year following treatment than the continuous reinforcement procedure. Finally, we predict that the intermittent unpredictable schedule will produce longer lasting behavior change than the intermittent predictable schedule. Methamphetamine use will be measured using urine toxicology and self-report of methamphetamine use.


Clinical Trial Description

Briefly the four study conditions are: (1) standard treatment which consists of 16 weeks of psychosocial treatment, (2) continuous contingency management which consists of 16 weeks of psychosocial treatment with a contingency management procedure in effect during the first twelve weeks in which vouchers are made available after each provision of a methamphetamine-negative urine test, (3) intermittent predictable contingency management which consists of 16 weeks of psychosocial treatment with a contingency management procedure in effect during the first twelve weeks in which vouchers are available after the provision of every three consecutive methamphetamine-negative urine samples, and (4) intermittent unpredictable contingency management which consists of 16 weeks of psychosocial treatment with a contingency management procedure in effect during the first twelve weeks in which vouchers are available on one day each week (randomly selected after the first week) for the provision of methamphetamine-negative urine samples provided all urine samples since delivery of the last reinforcer were also methamphetamine negative. ;


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00158197
Study type Interventional
Source Friends Research Institute, Inc.
Contact
Status Completed
Phase N/A
Start date December 2004
Completion date June 2008

See also
  Status Clinical Trial Phase
Completed NCT02232789 - Abuse Liability and Human Pharmacology of Mephedrone Phase 1
Completed NCT01449565 - Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM) Phase 2
Completed NCT00247572 - Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories Phase 2
Active, not recruiting NCT00100074 - To Assess the Safety and Tolerability of 7.5, 15 and 30 mg of Sublingual Lobeline. - 1 Phase 1
Active, not recruiting NCT00033072 - Assessment of Potential Interactions Between Methamphetamine and Selegiline - 1 Phase 1
Recruiting NCT06145698 - Treatment Effect of Cross-frequency Transcranial Alternating Current Stimulation on the MUD N/A
Completed NCT00990067 - Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) Phase 1
Completed NCT02797990 - Conflict Between Maternal Autonomy and Child Health in Substance-use N/A
Recruiting NCT01899313 - A Cognitive Behavioral Therapy-Based Text Message Intervention for Methamphetamine Dependence N/A
Active, not recruiting NCT00265278 - Assessment of Interactions Between Intravenous Methamphetamine and Modafinil - 1 Phase 1
Active, not recruiting NCT00000350 - Effects of Stimulant Dependence on Human Striatal Dopamine System - 15 Phase 1
Active, not recruiting NCT00089440 - Assessment of Interactions Between Methamphetamine and Aripiprazole - 1 Phase 1
Active, not recruiting NCT00040040 - Assessment of Potential Interactions Between Methamphetamine and Bupropion - 1 Phase 1
Completed NCT00040053 - Ondansetron for the Treatment of Methamphetamine Dependence - 1 Phase 2
Completed NCT00895804 - Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine) Phase 1
Recruiting NCT03902405 - Computerized Exercise to Alter Stimulant Approach Responses N/A
Recruiting NCT04982796 - Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder Phase 1/Phase 2
Completed NCT01386177 - Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA) Phase 1
Completed NCT01136278 - Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA) Phase 1
Completed NCT00069251 - Bupropion for the Treatment of Methamphetamine Dependence - 1 Phase 2