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Clinical Trial Summary

Demethylating agent decitabine enhances the immunogenicity of leukemia cells by inducing the expression of cancer testis antigens (CTAs),MHC class I and II molecules,costimulatory molecules and adhesion molecules. The leukemias cells treated by decitabine will become more sensitive to the following adoptive T cell therapy.We proposed a hypothesis that decitabine-based chemotherapy acts in synergestic with haploidentical lymphocyte infusion in eliciting leukemia specific cytotoxic lymphocyte(CTL) and diminishing leukemic cells.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02662647
Study type Interventional
Source Chinese PLA General Hospital
Contact
Status Completed
Phase Phase 2
Start date April 2015
Completion date March 2019

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