Natural Killer(NK) Cell Therapy Targeting CLL1 in Acute Myeloid Leukemia

Status Recruiting

Clinical Trial Summary

This is a phase 1, first-in-human (FIH), open-label, multicohort study to evaluate the safety, tolerability and preliminary efficacy of CLL1 target CAR iPSC NK cells in patients with relapsed/refractory AML

Clinical Trial Description

Acute myelogenous leukemia (AML) is a potentially cur-able disease; 70% of newly diagnosed patients achievecomplete remission with first-line therapy, but prognosisworsens for relapsed disease in both pediatric and adultpatients. CLL-1 has attracted the researchers' attention due to its high expression in AML while being absent in normal hematopoietic stem cell. Accumulating evidence have demonstrated CLL-1 is an ideal target for AML. ;

Study Design

Related Conditions & MeSH terms

AML, Adult

Clinical Trial Details

NCT number	NCT06027853
Study type	Interventional
Source	Zhejiang University
Contact	He Huang, MD
Phone	+8613605714822
Email	hehuangyu@126.com
Status	Recruiting
Phase	Phase 1
Start date	September 10, 2023
Completion date	August 31, 2026

View Details

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