Alzheimer Disease Clinical Trial
— AMIMAGE 2Official title:
STUDY OF IMAGING MARKERS IN THE VERY EARLY STAGES OF DEMENTIA AMONG RETIRED RURAL FARM IN THE GIRONDE AND PARTICIPATING IN THE AMI COHORT EPIDEMIOLOGY: A LONGITUDINAL STUDY.
Verified date | March 2017 |
Source | University Hospital, Bordeaux |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
It is now acknowledged that Alzheimer's disease is characterized by a long period of pathophysiological change. Developing new strategies to achieve diagnoses as early as possible has become a major goal for therapies aimed at slowing the progression of this disease. While diagnoses currently rely principally on clinical neuropsychology, the typical diagnostic criteria of NINCDS-ADRDA are inapplicable in the early stage of the disease. The goal of our project is to identify very early imaging markers for Alzheimer's disease among patients with no report of cognitive difficulties. In order to achieve this goal, we propose a longitudinal study in an elderly population cohort.
Status | Completed |
Enrollment | 304 |
Est. completion date | June 2015 |
Est. primary completion date | June 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - At least 65 years old - Be retired from agricultural profession - live in rural area in Gironde (France) Exclusion Criteria: - Lefthanded - having a dementia (MMSE < 13) - Having a vascular cerebral accident - Parkinson disease - RMI exclusion criteria - [18F]-FDG PET SCAN exclusion criteria - Poor health condition does not allowing transport to neuroimaging service |
Country | Name | City | State |
---|---|---|---|
France | Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux | Bordeaux |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Measures of volume and diffusion parameters in the gray matter (hippocampus and cingular posterior cortex) | Inclusion (Day 0) | ||
Secondary | Performance on neuropsychological and daily life cognitive tests | Everyday up to Day 7 after inclusion |
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