Alzheimer Disease Clinical Trial
Beta amyloid immunoreactivity is probably due to a significant number of Ab catabolites
corresponding to N-terminally truncated and Cterminally truncated or extended forms which
display distinct propensity to aggregation. Very few things are known concerning the
mechanisms and proteases by which they are generated. Furthermore, the link between
truncation and toxicity has not been delineated.
Finally, little is known concerning Ab fragments in biological fluids and whether they could
be seen as early biomarkers and thereby, as putative targets for AD diagnostic. The present
project will allow to examine the human biological samples and to identify various cohorts
after complete clinical evaluation.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 2012 |
Est. primary completion date | September 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - 1) Coming subjects to see patients in CMRR for a complaint mnésique 2) Introducing a score in Tiny Mental the upper Test (MMSE) in 28/30 without error in under score of the recall of the 3 words 3) Introducing a score of 10/10 in the test of the 5 words of B2C 4) Introducing a score in the ladder CDR (Clinical Dementia Rating) equal to 0 5) Having given a lit consent 6) Being affiliated member or beneficiary of the regime of French national health and pensions organization Exclusion Criteria: - Major, all the vulnerable persons under 18 under tutelage, under legal guardianship, deprived of freedom, hospitalized in a health Establishment or social for quite other reason that searches it - Record of neurological or psychiatric pathology and inability for sensory reasons to perform a cognitive balance sheet |
Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
France | Robert | Nice | Alpes-Maritimes |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Nice |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Identification of yet unknown enzymes involved in the processing of Ab, especially on those responsible for the exoproteasic truncation of Ab at its N-terminus. | Identification of yet unknown enzymes involved in the processing of Ab, especially on those responsible for the exoproteasic truncation of Ab at its N-terminus. | one year | No |
Secondary | The availability of truncated fragments designed to set up monoclonal antibodies will allow us to estimate their associated toxicity in various cellular models. | Secondly, the availability of truncated fragments designed to set up monoclonal antibodies will allow us to estimate their associated toxicity in various cellular models. Furthermore, we will be able to compare the toxicity of soluble monomers and aggregates. Third, we expect to determine the content of these Ab species in the biological fluids of various representative non-demented or AD affected patients. | one year | No |
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