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Alzheimer Disease clinical trials

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NCT ID: NCT06257563 Withdrawn - Alzheimer Disease Clinical Trials

Toolkit for Experiential Well-beiNg in Dementia (TEND)

TEND
Start date: February 2024
Phase: N/A
Study type: Interventional

The goal of this project is to conduct an open pilot (N=5) among dyads (persons living with dementia and their caregivers) to assess the preliminary effects of an online videogame platform. The "Isle of TEND" is an immersive and interactive videogame platform designed for persons living with dementia and their caregivers. Dyads will use the platform three to four times a week for 20-30 minutes across four weeks. The investigators will assess for improvements in relationship satisfaction, wellbeing, and positive emotions and gather feedback on engagement in the platform. Dyads will complete measures at baseline and post-intervention as well as brief measures after each platform use.

NCT ID: NCT06220292 Withdrawn - Alzheimer Disease Clinical Trials

Intermittent Oral-esophageal Tube Feeding in Alzheimer's Patients With Dysphagia

Start date: January 30, 2024
Phase: N/A
Study type: Interventional

This is a prospective multicenter study with Alzheimer's patients with dysphagia. Patients enrolled are randomly divided equally into the observation group and the control group. All patients receive conventional care, and the observation group received Intermittent Oral-esophageal Tube Feeding while the control group received Nasogastric Tube Feeding for enteral nutrition support. Baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life after treatment are compared.

NCT ID: NCT05921929 Withdrawn - Clinical trials for Major Depressive Disorder

First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)

Start date: May 2, 2024
Phase: Phase 1
Study type: Interventional

The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: - What is the safety of single ascending doses of the FluoroEthylNorMemantine (FENM)? - What is the PK profile of single ascending doses of the FENM in human? - What is the preliminary exploratory time course of Brain Disease Neurotrophic Factor (BDNF) plasmatic levels of single ascending doses of the FENM? Participants will receive one single oral dose of FENM.

NCT ID: NCT05728736 Withdrawn - Alzheimer Disease Clinical Trials

Acute Effect of Lemborexant on CSF Amyloid-Beta and Tau

Start date: March 1, 2023
Phase: Phase 2
Study type: Interventional

This study will look at the effects of lemborexant on Alzheimer's disease biomarkers found in the cerebrospinal fluid (CSF) and blood in individuals who are poor sleepers

NCT ID: NCT05497817 Withdrawn - Dementia Clinical Trials

A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Dementia

Start date: September 2022
Phase: N/A
Study type: Interventional

This research is being done to develop a unique matching process for caregivers of persons living with dementia, such as Alzheimer's disease, Lewy body dementia, frontotemporal degeneration, or other dementia syndromes. Dementia caregivers often assume greater caregiving burden than do non-dementia caregivers, and the caregiving duration tends to be longer. Many caregivers do not have the adequate support they need. Peer-to-peer support has been shown to improve quality of life, increase use of services, improve caregiver health, and reduce hospitalizations in the person they are caring for. This study will assess a technology platform and matching process for the purpose of peer-to-peer emotional support aimed at improving overall wellbeing in dementia care partners/caregivers.

NCT ID: NCT05402423 Withdrawn - Alzheimer Disease Clinical Trials

An Integrated Intervention of Computerized Cognitive Training and Physical Exercise in Virtual Reality for People With Alzheimer's Disease (JDome)

JDome
Start date: June 27, 2022
Phase: N/A
Study type: Interventional

JDOME is a randomized controlled trial to test the effectiveness of a computerized cognitive training with the Brainer web platform and aerobic training with the JDOME system vs. a computerized cognitive training with the Brainer web platform and aerobic training with a standard exercise bike in subjects with Alzheimer's Disease at early stage. The JDome BikeAround is a tool that take people with dementia on a virtual bicycle tour along the paths of memories. It combines an exercise bike, a dome-shaped projector and Google Street View technology.

NCT ID: NCT05332678 Withdrawn - Alzheimer's Disease Clinical Trials

SLS-005 (Trehalose Injection) in the Treatment of Alzheimer's Disease

[STRIVE-AD]
Start date: March 3, 2023
Phase: Phase 2
Study type: Interventional

An open-label, proof-of-concept study to evaluate the safety and treatment effects of SLS-005 in Participants with Alzheimer's Disease (AD) treated once or twice weekly for 52 weeks.

NCT ID: NCT05321498 Withdrawn - Alzheimer Disease Clinical Trials

Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflammation

Start date: June 2023
Phase: Phase 2
Study type: Interventional

The goal of this Phase 2 MCI study is to determine whether 1.0 mg/kg XPro1595 is superior to placebo at improving measures of cognition, functioning and brain quality in individuals with MCI and biomarkers associated with neuroinflammation (APOE4) and to evaluate safety, tolerability, and efficacy of XPro1595.

NCT ID: NCT05032482 Withdrawn - Clinical trials for Mild Alzheimer's Disease

WeArable Neuromodulation DeVice for the TrEatment of Alzheimer's Disease

WAVE-AD
Start date: December 2023
Phase: N/A
Study type: Interventional

This is a double- blind, randomized controlled trial with an open label extension designed to evaluate the safety and potential efficacy of a non-invasive brainstem neuromodulation device for treating symptoms associated with Alzheimer's disease (AD).

NCT ID: NCT04942184 Withdrawn - Alzheimer Disease Clinical Trials

STRATEGIES to Improve Memory in Alzheimer's Disease

Start date: October 2022
Phase: N/A
Study type: Interventional

Memory mistakes are one of the most detrimental symptoms in Alzheimer's Disease (AD). In this study the investigators will measure the long-term efficacy of memory strategies in patients with AD. First, the efficacy of the strategies will be evaluated in the laboratory by analyzing the behavioral response and the brain activity of the patients. During the first visit, patients will be taught the memory strategies and asked to repeat them at home for 4 weeks. During this period of time, patients will perform several memory tasks while their performance and brain activity will be measured using portable devices. Monitoring brain activity and behavioral responses to memory tasks will provide insightful information on the efficacy of the strategies and allow the investigation of how patients can maintain the strategies over time. The research will examine if improving memory through the use of cognitive strategies, can positively affect other domains of daily life.