| Eligibility |
Inclusion Criteria
- Cognitively normal subjects aged 65 to 90 years and prodromal to mild AD subjects aged
50 to 90 years, inclusive at the time of screening.
- Prodromal to moderate AD subjects: Meet the National Institute on Aging - Alzheimer's
Association (NIA-AA) core clinical criteria for mild cognitive impairment (MCI) due to
AD, probable AD dementia or AD dementia
- Have a Clinical Dementia Rating (CDR) score of 0 (cognitively normal) or 0.5
(prodromal to moderate AD) at screening
- Have an Mini-Mental State Examination (MMSE) score 10-30 inclusive
- Have Aß PET imaging demonstrating Aß binding based on qualitative visual read at
screening or using an acceptable historical PET scan (cognitively normal subjects will
be assessed with Aß PET at screening but will not be required to demonstrate Aß
binding).
- A brain MRI consistent with normal cognition or that supports a diagnosis of prodromal
to moderate AD, with no evidence of other significant neurologic pathology. A
previously acquired research MRI within the last 12 months may be used if deemed
acceptable by the investigator and no significant clinically relevant changes have
occurred since the prior MRI was obtained
- The subject has an appropriate study partner capable of participating in CDR
assessment and, if necessary, of accompanying the subject
- For cognitively normal subjects only: History of at least one first degree relative
with diagnosis of Alzheimer's disease (self-reported by the potential subject and/or
confirmed by the study partner).
Exclusion Criteria
- Current or prior history of any alcohol or drug abuse within the last 2 years
- Prior participation in other research protocols or clinical care in the last year in
addition to the radiation exposure expected from participation in this clinical study,
such that radiation exposure exceeds the effective dose of 50 millisievert (mSv),
which would be above the acceptable annual limit established by the US Federal
Guidelines
- Evidence of clinically significant gastrointestinal, cardiovascular, hepatic, renal,
hematological, neoplastic, endocrine, alternative neurological, immunodeficiency,
pulmonary, or other disorder or disease
- MRI evidence of cerebrovascular disease, infectious disease, space-occupying lesions,
normal pressure hydrocephalus, or other central nervous system (CNS) disease
- Implants that have not been certified for MRI or history of claustrophobia in MRI,
unless an acceptable previously acquired research MRI is available
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