Vitamin D and Periodontitis

Alveolar Bone Loss Clinical Trial

Official title:

Relationship of Bone Metabolism Biomarkers and Serum 25-Hydroxy Vitamin D in Patients With Chronic Periodontitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03088488
• Other study ID #: OrduUniversity
• Status: Completed
• Phase: N/A
• First received: March 10, 2017
• Last updated: March 16, 2017
• Start date: June 1, 2015
• Est. completion date: April 21, 2016

Study information

• Verified date: March 2017
• Source: T.C. ORDU ÜNIVERSITESI
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: April 21, 2016
• Est. primary completion date: March 15, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 25 Years to 45 Years

Eligibility

• Inclusion Criteria:

• never-smokers

• no history of systemic disease

• no patients had been under periodontal therapy and medicine for at least 6 months before the study

• no pregnancy or lactation

• no alcohol or antioxidant vitamin consumption.

• Exclusion Criteria:

Related Conditions & MeSH terms

• Alveolar Bone Loss
• Periodontitis

Intervention

Diagnostic Test:
• fasting venous blood samples

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
T.C. ORDU ÜNIVERSITESI

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Biochemical parameters	serum TNF-a	Baseline
Primary	Biochemical parameters	serum CTx	Baseline
Primary	Biochemical parameters	serum RANKL	Baseline
Primary	Biochemical parameters	serum OPG	Baseline
Primary	Biochemical parameters	serum 25-OH vitamin D	Baseline
Secondary	Periodontal parameters	The plaque index (PI)	Baseline
Secondary	Periodontal parameters	gingival index (GI)	Baseline
Secondary	Periodontal parameters	probing depth (PD)	Baseline
Secondary	Periodontal parameters	clinical attachment level (CAL)	Baseline