Allograft Clinical Trial
Official title:
Feasibility Study of Platelet Activation and Inflammatory Response of Platelets in Hematopoietic Stem Cell Allograft Patients Post-transplant: Spontaneously and After Stimulation by an CMV Antigen
Traditionally known for their role in haemostasis, platelets have also an immune role.
Platelets play a key role in immune mediator secretion, and interact with innate and adaptive
immune cells, contributing to the fight against pathogens, as viruses.
Cytomegalovirus (CMV) is responsible of allograft patients' serious infections, because of
the induced immune depression. Platelets activation for patients is not determined during the
post-graft period, and platelet induced inflammation following a CMV infection is not
described.
The descriptive present study will determine if platelet activation is altered during the
post-graft follow-up (day 30 to 90).
The activation will be studied spontaneously and after simulation by a CMV (Cytomegalovirus)
antigen.
The study will also focus on inflammatory response variation, focusing on the cytokines
release during the same post-graft follow-up (spontaneously and after CMV antigen
stimulation).
This preliminary study could lead to a better understanding of the immune-modulator role of
inflammation, controlled by the platelets, particularly in the initiation of the
Graft-versus-host disease in this kind of population.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05536492 -
Sticky Bone Compared to A-PRF(Platlet Rich Fibrin) Effect on Alveolar Ridge Preservation
|
N/A | |
| Completed |
NCT00384540 -
Cardiac Allograft Vasculopathy and Dobutamine Stress Echocardiography / Brain Natriuretic Peptide Coupling
|
N/A | |
| Recruiting |
NCT02882828 -
PK Assessment of Tacrolimus Exposure Before and After a Switch From Twice Daily Immediate-release (Prograf®) to Once-daily Prolonged Release Tacrolimus (Envarsus®)
|
Phase 4 | |
| Completed |
NCT02444052 -
Evaluation of Zimmer Puros® Allograft vs. Creos™ Allograft for Alveolar Ridge Preservation
|
N/A | |
| Terminated |
NCT04021316 -
Decellularised Dermis Allograft for the Treatment of Chronic Venous Leg Ulceration
|
N/A | |
| Completed |
NCT00894049 -
A Study Comparing Non Myeloablative (Flu-TBI) and Reduced Intensity (FLU-BU-ATG) Conditioning in Allogenic Transplantation
|
Phase 2 | |
| Recruiting |
NCT03402776 -
Impact of a Fourth Hexavalent Vaccine After Hematopoietic Stem Cell Transplantation
|
Phase 3 | |
| Completed |
NCT03829072 -
Cooking Education and Adapted Physical Activity in Allografted Patients
|
N/A | |
| Terminated |
NCT05258929 -
RElapse After Allograft: Link Between LoCus of Control and QualiTy of Life
|
||
| Recruiting |
NCT05096351 -
Immunological Reaction of the Recipient After Cold-stored Saphenous Venous Allograft (Bioprotec)
|
||
| Not yet recruiting |
NCT05459181 -
HeartCare Immuno-optimization in Cardiac Allografts (MOSAIC)
|
N/A | |
| Recruiting |
NCT05164835 -
Study of Drug Acceptance and Its Persistence Over Time in Patients Receiving a Haematopoietic Stem Cell Allograft
|
N/A | |
| Recruiting |
NCT05510011 -
Allograft and Tantalum Cone Reconstruction in TKA Revision
|
||
| Not yet recruiting |
NCT06219473 -
Efficacy of Fascia Lata Allograft and Platelet Rich Fibrin on the Periodontal Phenotype Around Dental Implant
|
Phase 4 | |
| Withdrawn |
NCT05423496 -
KidneyCare Immuno-optimization in Renal Allografts (KIRA)
|
N/A | |
| Completed |
NCT00876148 -
Risk of Hepatitis B Virus Reactivation in Patients Undergoing Allografting
|
N/A |