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Suvorexant and Alcohol

Alcohol Use Disorder Clinical Trial

Official title:
Influence of Orexin Antagonism on Motivation for Alcohol

Clinical Trial Summary

This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people with Alcohol Use Disorder. This study will also provide basic science information about the orexinergic mechanisms underlying the pharmacodynamic effects of alcohol in humans. As such, the outcomes will contribute to our understanding of the clinical neurobiology of Alcohol Use Disorder. Overall, the proposed work seeks to expand the scope of current clinical neuroscience research on alcohol addiction by focusing on orexin, which has strong preclinical evidence supporting its critical role in addiction but remains unstudied in humans.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06326684
Study type Interventional
Source University of Kentucky
Contact William W Stoops, PhD
Phone 8592575388
Email william.stoops@uky.edu
Status Recruiting
Phase Early Phase 1
Start date June 7, 2024
Completion date March 15, 2027
View Details
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