Metabolism in the Human Brain Following Consumption of a Keto-ester in

Status Recruiting

Clinical Trial Summary

The objective of this study is to determine whether BHB levels in the brain will be positively associated with alcohol consumption, due to hypothesized enhancement of BHB transport into the brain.

Clinical Trial Description

The primary objective of this study is to determine whether BHB levels in the brain will be positively associated with alcohol consumption, due to hypothesized enhancement of BHB transport into the brain. Furthermore, BHB levels in identified brain regions will be compared against measures of craving. The secondary objective of this study is to investigate if GABA levels will be elevated in key brain regions relative to the baseline scan in AC subjects due to preferential BHB metabolism. The goal is to acquire preliminary data to apply for an R01 or equivalent grant submission to pursue this metabolic therapy in greater detail using the state-of-the-art MRSI platform at Yale University to study alcohol use disorders. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05937893
Study type	Interventional
Source	Yale University
Contact	Chathura Kumaragamage, PhD
Phone	(203) 785-5296
Email	chathura.kumaragamage@yale.edu
Status	Recruiting
Phase	N/A
Start date	August 14, 2023
Completion date	October 2024

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Metabolism in the Human Brain Following Consumption of a Keto-ester in Alcohol Use Disorder (AUD) With Proton Magnetic Resonance Spectroscopic Imaging (MRSI)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms