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Clinical Trial Summary

This pilot study will seek evidence that oxytocin, compared to placebo, reverses tolerance and alcohol seeking in humans.


Clinical Trial Description

This pilot study will seek evidence that intranasal oxytocin reverses tolerance and alcohol seeking in humans by employing state-of-the-art computer-assisted intravenous alcohol administration. Two separate experiments will be run. In the first, tolerance will be assessed using sensitive tests of subjective response and cognitive function during an intravenous infusion that maintains a steady breath and therefore brain exposure to alcohol. In the second, an intravenous alcohol self-administration paradigm that requires increasing effort for each additional infusion will be used to assess change in motivation for alcohol. Demonstrating that oxytocin (compared to placebo) worsens test performances in alcohol-dependent individuals and/or reduces the compulsive drive to self-administer alcohol would be strong evidence for its potential to treat alcohol use disorders. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05312008
Study type Interventional
Source Indiana University
Contact
Status Terminated
Phase Phase 2
Start date January 16, 2022
Completion date December 21, 2023

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