Alcohol Use Disorder Clinical Trial
Official title:
Transcranial Direct Current Stimulation of the Bilateral Dorsolateral Prefrontal Cortex for Alcohol Use Disorders: A Randomised, Sham-controlled Clinical Trial
Transcranial direct current stimulation (tDCS) is a non-invasive, safe and easy-to-operate
neuro-electrophysiological technique, which becoming an emerging therapeutic option for many
mental disorders.It can modulate cortical excitability of target brain region, neuron
plasticity and brain connections. Previous studies suggest that tDCS could reduce cue-induced
craving in drug addiction.
Objective:In this study, the investigators employed real and sham tDCS of the bilateral
dorsolateral prefrontal cortex (DLPFC) to test the effect of whether it could reduce
cue-induced craving, influence cognitive function in alcoholics and explore its underlying
mechanism with functional magnetic resonance imaging (fMRI).
Methods: The investigators perform a randomized sham-controlled study in which 40 inpatient
alcoholics will be randomized to receive 10 sessions of 20min sham or 1.5mA tDCS to the
bilateral DLPFC (anodal right/cathodal left). The neuroimaging data, craving after exposed to
alcohol-associated cues and the cognition task at baseline and after stimulation will be
collected.
The investigators hypothesized that tDCS stimulating the DLPFC decreases cue-induced craving
and improves cognition, which might be associated with the functional connectivity
alterations.
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