Alcohol Use Disorder Clinical Trial
Official title:
Study of Mechanisms of Emotion Regulation in Short- and Long-term Alcohol-abstinent Patients
Background:
Difficulties in assigning and identifying emotional states, or to regulate the emotional
costs are recognized as one of the major factors of relapse. This study aimed to evaluate the
emotion regulation processes, in short term (STA, after 1month of withdrawal) and long-term
alcohol abstinent individuals (LTA, at least six months of abstinence), compared to healthy
control participants (C) in a positive and negative emotion induction protocol.
Main aim:
Evaluating the emotional regulation deficits assessed with physiological indicators (heart
rate variability, electrodermal response, pupil diameter) and clinically in presentations of
visual stimuli to emotional value (positive, negative, neutral) in alcohol use disorder's
(AUD) patients with short and long term abstinent compared to a control group of healthy
subjects. The investigators are particularly interested in the evolution of heart rate
variability considered as a good marker of vulnerability to AUD.
Secondary objectives:
Studying the relationships between physiological measures and clinical variables such as
behavioral indicators and self-reported assessment of cognitive and emotional skills among
the three groups (STA, LTA and C).
The recording was performed for all participants during presentation of high emotional
inducing stimuli presenting human interactions (pictures and video sequences). For each
participant physiological responses (pupil diameter, heart rate, and skin conductance) were
recorded before, during and after induction.
Participants were asked to evaluate the intensity and the valence of emotional stimuli.
In addition, a neurological evaluation, a clinical and cognitive assessment were performed.
Neurological, clinical and cognitive evaluation - Each participant had a clinical structured
interview, a neurological evaluation, self-administered assessment (Hospital Anxiety &
Depression Scale, Emotional Skills Profile, Obsessive Compulsive Drinking Scale, and
cognitive assessment (Montreal Cognitive Assessment).
Physiological assessment - The recording was performed for all participants during the
presentation of pictures (static stimuli) or videos (dynamic stimuli) selected according to
their high emotional intensity (positive, neutral and negative valence), representing human
interactions. For each participant heart rate, electrodermal activity, and pupil diameter
were recorded during three experimental conditions: rest, induction (presentation of stimuli)
and after induction (recovery). Participants were asked to evaluate the intensity and valence
of the pictures and videos using the Self-Assessment Manikin.
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