Learning and Relapse Risk in Alcohol Dependence (FP2)

Alcohol Use Disorder Clinical Trial

— LeAD_FP2  

Official title:

Learning and Decision Making as Predictors of Treatment Outcome in Alcohol Use Disorder (Funding Period 2)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02615977
• Other study ID #: HE2597/142;ZI1119/32;WI709/102
• Status: Completed
• Phase: N/A
• Start date: April 2015
• Est. completion date: June 2020

Study information

• Verified date: July 2020
• Source: Technische Universität Dresden
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators will examine clinical alterations in learning and automated approach behaviour and their neurobiological correlates in alcohol-dependent patients and healthy social drinkers and assess whether they are affected by a Zooming Joystick Training (ZJT; randomized "verum" versus "placebo" training) which trains subjects to habitually push alcohol pictures away.

The investigators will test whether activations following treatment predict relapse rate (primary outcome measure) and the prospective amount of alcohol intake (secondary outcome measure) within a six-month follow-up period.

Using fMRI, the investigators will use the Pavlovian-to-Instrumental-Transfer (PIT) paradigm established during the first funding period to distinguish the effects of appetitive, aversive, and drug-related Pavlovian cues on automated instrumental approach behaviour and to assess ZJT training effects comparing functional activation before and after ZJT training.

The investigators will also scan subjects during performance of a short standard working memory task. Behaviourally, aspects of impulsivity will be assessed with the Value-Based Decision Making (VBDM) Battery. Scanning will be repeated after ZJT training to assess its effects on the neural correlates of Pavlovian-to-Instrumental transfer (PIT).

Description:

This Project will examine 130 detoxified alcohol-dependent patients and 40 age- and gender matched controls. All subjects will be treated with Zooming Joystick Task (ZJT) training to alter a habitual alcohol cue approach bias. The primary aim of this project is to assess

1. which behavioural and neuroimaging alterations (fMRI) associated with reward-based learning are altered by ZJT treatment and which alterations predict treatment outcome (primary outcome: relapse, secondary outcome: amount of alcohol intake) within the follow-up period of 6 months,

2. how these alterations interact with clinical and psychosocial factors that can modify relapse risk, and

3. to provide data for genetic and imaging analyses and modelling. Furthermore, the investigators will explore gender effects on functional imaging parameters of learning.

Patients will be detoxified in an inpatient setting, receive six sessions of the ZJT in a randomized placebo controlled design and will be followed for six months using the Time-Line Follow-Back Procedure. Clinical assessments, behavioural paradigms of learning, and brain imaging will be carried out within at least four half-lives after any psychotropic medication. Subjects will undergo medical management with biweekly follow-ups and predefined inclusion and exclusion criteria as previously described. Functional imaging paradigms will be applied, assessing

1. Pavlovian-to-instrumental transfer,

2. habitual versus goal directed behaviour and

3. working memory.

The investigators will associate model parameters of learning with functional activation and prospective intake controlling for comorbidity, psychosocial and neurobiological disease severity markers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 258
• Est. completion date: June 2020
• Est. primary completion date: August 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Men and women aged 18-65 years

• alcohol dependence/alcohol use disorder according to ICD-10 and alcohol-use disorder according to DSM-5

• Minimum of 72 hours of abstinence, maximum of 21 days of abstinence

• Minimum of three years with alcohol dependence/alcohol use disorder

• Low severity of withdrawal symptoms

• Ability to provide fully informed consent and to use self-rating scales

• Sufficient understanding of the German language

Exclusion Criteria:

• Lifetime history of DSM-IV bipolar, psychotic disorder, or substance dependence other than nicotine dependence. Patients may have had lifetime alcohol dependence/alcohol use disorder diagnoses.

• Current threshold DSM-IV diagnosis of any of the following disorders: current (hypo)manic episode, major depressive disorder, generalized anxiety disorder, PTSD, borderline personality disorder, or obsessive compulsive disorder

• History of substance dependence other than alcohol or nicotine dependence

• Current substance use other than nicotine and alcohol as evinced by positive urine test

• History of severe head trauma or other severe central neurological disorder (dementia, Parkinson's disease, multiple sclerosis)

• Pregnancy or nursing infants

• Any alcohol intake within the last 24 hours

• Use of medications or drugs known to interact with the central nervous system within the last 10 days, except detoxification treatment with benzodiazepines or clomethiazole, with testing at least four half-lives post last intake

Related Conditions & MeSH terms

• Alcohol Drinking
• Alcohol Use Disorder
• Alcoholism

Intervention

Behavioral:
• Zooming Joystick Task
Subjects are instructed to use the joystick to pull all pictures (alcoholic and non-alcoholic beverages) towards them that appear in the portrait format, while pictures in a landscape format are pushed away. Half of the pictures are alcohol-related and the other half is not. The assignment of stimuli (alcohol versus neutral) to the picture format (portrait versus landscape) is manipulated (see 'Study Arm' descriptions). Arousal and valence of the alcohol and non-alcohol pictures is rated as previously described. The investigators will apply six sessions of ZJT training, as this number has been proven sufficient for reducing relapse rates.
• Zooming Joystick Task (Placebo)
Subjects are instructed to use the joystick to pull all pictures (alcoholic and non-alcoholic beverages) towards them that appear in the portrait format, while pictures in a landscape format are pushed away. Half of the pictures are alcohol-related and the other half is not. The assignment of stimuli (alcohol versus neutral) to the picture format (portrait versus landscape) is manipulated (see 'Study Arm' descriptions). Arousal and valence of the alcohol and non-alcohol pictures is rated as previously described. The investigators will apply six sessions of ZJT training, as this number has been proven sufficient for reducing relapse rates.

Locations

Country	Name	City	State
Germany	Charité - Universitätsmedizin Berlin	Berlin
Germany	Technische Universität Dresden	Dresden
Germany	Universitaetsklinikum Carl Gustav Carus at the Technische Universitaet Dresden	Dresden	Saxony

Sponsors (3)

Lead Sponsor	Collaborator
Technische Universität Dresden	Charite University, Berlin, Germany, University Hospital Carl Gustav Carus

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	relapse to heavy drinking	defined as the consumption of over 60g of alcohol per occasion in men and of over 40g of alcohol in women	6 months
Secondary	amount of alcohol intake during the follow-up period	Timeline Followback interview for each day during the follow-up period	6 months
Secondary	blood oxygenation level-dependent (BOLD) signal		at assessment and after last training (approx. 2 weeks after assessment)

External Links

•   English study description
•   Official study group website