Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment

Alcohol Intoxication Clinical Trial

Official title:

The Impact of Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06293040
• Other study ID #: IRB00434441
• Secondary ID: R01DA052295
• Status: Not yet recruiting
• Phase: Phase 1
• Start date: June 2024
• Est. completion date: December 2027

Study information

• Verified date: February 2024
• Source: Johns Hopkins University
• Contact: Tory Spindle, PhD
• Phone: 410-550-0529
• Email: tspindle[@]jhmi.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis. Participants (n=32) will complete 7 double-blind, double-dummy outpatient sessions in randomized order. In each session, participants will self-administer placebo (0 mg THC) or active vaporized cannabis (5 or 25 mg THC, via a handheld vaporizer called the Mighty Medic) and a placebo drink (BAC 0.0%) or alcohol drink calculated to produce a breath alcohol concentration (BAC) of 0.05%. Participants will also complete a positive control session in which the participant administers placebo cannabis and alcohol at a target BAC of 0.08% (the legal threshold for driving impairment in most U.S. states).

Description:

This study will be conducted at the Johns Hopkins Behavioral Pharmacology Research Unit (BPRU). Participants will complete a screening visit, and, if eligible, will then complete 7 experimental drug administration sessions in randomized order where the participant will vaporize cannabis-containing capsules (or "pods") (containing 0, 5, or 25mg THC) with a drink that contains no alcohol or alcohol (alcohol-containing drinks will be calculated to produce a breath alcohol concentration, BAC, of 0.05%). There is also a positive control session where participants will vaporize placebo cannabis with an alcohol drink calculated to produce a BAC of 0.08%. Each session will last approximately 8 hours and will be separated by at least 48 hours to allow for sufficient drug washout. Participants may complete up to 2 sessions per week. Drugs will be administered in a double-blind and double-dummy fashion (i.e., participants will always receive both active or placebo cannabis and active or placebo alcohol). During each session, a battery of assessments including blood collection, subjective questionnaire administration, cognitive performance testing, and simulated driving will be conducted.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 90
• Est. completion date: December 2027
• Est. primary completion date: June 2027
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

1. Have provided written informed consent

2. Be at least 21 years of age

3. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests

4. Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at each study visit

5. Have not donated blood in the prior 30 days

6. Report at least 1 day of binge drinking in the past 3 months (greater than 4 or 5 drinks on a single occasion for women and men, respectively)

7. Report at least 1 use of cannabis in the past 3 years

8. Provide negative urine test for illicit drug use (excluding THC) and negative breath alcohol test (0% BAC) at screening and before study sessions

9. Report at least 1 lifetime instance of simultaneous alcohol and cannabis use

10. Current concomitant prescription medication use that may interact with the investigational study drug, including inhibitors and inducers of CYP2CP and CYP3A4 as well as highly-protein bound drugs and drugs with a narrow therapeutic index such as warfarin, cyclosporine, and amphotericin B

Exclusion Criteria:

1. Psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in the past month

2. History of or current evidence of significant medical condition that would put the participant at risk

3. Evidence of current psychiatric condition (MINI for DSM-V)

4. Meet criteria for severe alcohol use disorder (MINI for DSM-V)

5. CIWA-Ar score > 9

6. Use of cannabis, on average, more than 3 days/week over past 3 months

7. Enrollment in another clinical trial or receiving of any drug as part of research within past 30 days

8. Shipley vocabulary score <18 (corresponds to 5th grade reading level)

Related Conditions & MeSH terms

• Alcohol Intoxication
• Alcoholic Intoxication
• Cannabis Intoxication
• Marijuana Abuse

Intervention

Drug:
• Cannabis
Cannabis will be vaporized using the Mighty Medic
• Alcohol
Alcohol will be orally ingested via a flavored drink
• Placebo Cannabis
Placebo cannabis (i.e., water vapor) will be vaporized using the Mighty Medic.
• Placebo Alcohol
A non-alcoholic, placebo, flavored drink will be orally ingested.

Locations

Country	Name	City	State
United States	Johns Hopkins Behavioral Pharmacology Research Unit	Baltimore	Maryland

Sponsors (2)

Lead Sponsor	Collaborator
Johns Hopkins University	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	DRUID application global impairment score	Acute cognitive and behavioral impairment will be assessed with global impairment score (range 0-100) on the DRUID app (higher scores indicate greater impairment).	Up to 6 hours
Primary	Correct Trials on Paced Auditory Serial Addition Task (PASAT)	Computerized version of Paced Auditory Serial Addition Task will be administered to assess working memory performance. Will report the total correct trials out of 90 recorded (lower scores indicate worse performance). Score ranges from 0-90, with 0 representing no correct trials and 90 representing 100% correct trials.	Up to 6 hours
Primary	Correct Trials on the Digit Symbol Substitution Task (DSST)	Computerized version of Digit Symbol Substitution Task will be administered to assess psychomotor performance. Will report the total correct trials in 90 seconds (lower scores indicate worse performance). There is no maximum score, with a score of 0 representing either no trials completed or no correct trials. The score reflects the number of correct trials.	Up to 6 hours
Primary	Cumulative score on Field Sobriety Tests	Impairment will be assessed using a battery of standard field sobriety tests including: the Horizontal Gaze Nystagmus Test (HGN), the Walk and Turn, the One Leg Stand, and the Modified Romberg Balance. The cumulative amount of clues observed across these tasks (out of a possible 22 clues) will be reported.	Up to 6 hours
Primary	Drug Effect Questionnaire (DEQ) - Feel Drug Effect	The DEQ will be used to obtain subjective ratings of "feel drug effects". Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Primary	Drug Effect Questionnaire (DEQ) - Feel High	The DEQ will be used to obtain subjective ratings of "feel high". Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Primary	Drug Effect Questionnaire (DEQ) - Confidence to Drive	The DEQ will be used to obtain subjective ratings of "confidence to drive". Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Primary	Drug Effect Questionnaire (DEQ) - Willingness to Drive	The DEQ will be used to obtain subjective ratings of "willingness to drive". Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Primary	Biphasic alcohol effects scale (BAES) - Sedative Score	The BAES is used to assess sedative and stimulant subjective effects of alcohol. There are 7 sedative-related questionnaire items, each presented on a scale of 0 (not at all) to 10 (extremely), which are integrated to produce an overall sedative score (0-70).	Up to 6 hours
Primary	Biphasic alcohol effects scale (BAES) - Stimulant Score	The BAES is used to assess sedative and stimulant subjective effects of alcohol. There are 7 stimulant-related questionnaire items, each presented on a scale of 0 (not at all) to 10 (extremely), which are integrated to produce an overall stimulant score (0-70).	Up to 6 hours
Primary	Subjective high assessment scale (SHAS)	For the SHAS, participants are presented with 13 questionnaire items, displayed on a visual analog scale anchored from 0 (normal) to 10 (extremely), which assess subjective effects of alcohol. These items are integrated to produce an overall SHAS score (0-130)	Up to 6 hours
Primary	Driving performance as assessed by standard deviation of lateral position (SDLP)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. SDLP (measured in cm) will be determined during each drive. This measure is a composite index of lateral control and incorporates lane weaving, swerving, and over-correcting. SDLP is the gold standard of quantifying the magnitude of driving impairment from drugs and alcohol and has excellent predictive validity to actual driving. Scores range from 0 to no upper limit. Higher scores represent higher magnitude of driving impairment.	Up to 6 hours
Primary	Driving performance as assessed by composite drive score	Driving impairment will be assessed via a composite drive score (higher scores indicate greater impairment). The composite drive score is derived by integrating various driving outcomes. There is no upper or lower limit to possible scores.	Up to 6 hours
Secondary	Driving performance as assessed by standard deviation of speed (SDSP)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. SDSP will be determined during each drive; this measure quantifies the variability in speed (in MPH) observed.	Up to 6 hours
Secondary	Driving performance (mean speed)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. Mean speed (in MPH) over the course of each drive will be determined.	Up to 6 hours
Secondary	Driving performance (number of speed exceedances)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. The cumulative number of times participants exceed the allowable speed limit during each drive.	Up to 6 hours
Secondary	Driving performance (number of accidents)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. The cumulative number of accidents (including car collisions, pedestrians hit, etc.) during each drive.	Up to 6 hours
Secondary	Driving performance (total rule violations)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. The cumulative number of rule violations (including number of missed stop signs, illegal turns, speed exceedances, etc.) during each drive.	Up to 6 hours
Secondary	Driving performance (distance to lead vehicles)	The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions. The mean distance (in meters) maintained to lead vehicles during car-following segments of each drive.	Up to 6 hours
Secondary	Attempted Trials on the Digit Symbol Substitution Task (DSST)	Computerized version of Digit Symbol Substitution Task will be administered to assess psychomotor performance. The number of attempted trials will be recorded	Up to 6 hours
Secondary	Percentage Correct on attempted trials on the Digit Symbol Substitution Task (DSST)	Computerized version of Digit Symbol Substitution Task will be administered to assess psychomotor performance. Percentage of correct trials out of those attempted will be recorded	Up to 6 hours
Secondary	Reaction time on Paced Auditory Serial Addition Task	Computerized version of Paced Auditory Serial Addition Task will be administered to assess working memory performance. The mean reaction time (in milliseconds) to select correct responses will be recorded.	Up to 6 hours
Secondary	Field Sobriety Test - Score on Horizontal Gaze Nystagmus Test	Impairment will be assessed using performance on the Horizontal Gaze Nystagmus Test (HGN). Total score will be recorded (out of possible 6 clues, score ranges from 0-6) with higher scores indicating higher impairment.	Up to 6 hours
Secondary	Field Sobriety Test - Score on Walk and Turn test	Impairment will be assessed using performance on the the Walk and Turn. Total score will be recorded (out of a possible 8 clues, score ranges from 0-8) with higher scores indicating higher impairment.	Up to 6 hours
Secondary	Field Sobriety Test - Score on One Leg Stand	Impairment will be assessed using performance on the One Leg Stand test. Total score will be recorded (out of a possible 4 clues, score ranges from 0-4) with higher scores indicating higher impairment.	Up to 6 hours
Secondary	Field Sobriety Test - Score on Modified Romberg Balance	Impairment will be assessed using performance on the Modified Romberg Balance test. Total score will be recorded (out of a possible 4 clues, score ranges from 0-4)) with higher scores indicating higher impairment.	Up to 6 hours
Secondary	Drug Effect Questionnaire - Like Drug Effect	The DEQ will be used to obtain subjective ratings of "like drug effect". Scores range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Secondary	Drug Effect Questionnaire - Want more	The DEQ will be used to obtain subjective ratings of "want more". Scores range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Secondary	Drug Effect Questionnaire - Dislike Drug Effect	The DEQ will be used to obtain subjective ratings of "dislike drug effect". Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.	Up to 6 hours
Secondary	Pharmacokinetics - CMax for THC and THC metabolites	Whole blood concentrations of THC, 11-OH- THC, and THCCOOH will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis. The maximum concentration (Cmax) is determined as the highest concentration reached for each individual. Characterizing these cannabinoids will allow for adequate control for individual differences in drug absorption and metabolism in statistical analyses and assist with interpretation of subjective and behavioral outcomes.	Up to 6 hours
Secondary	Pharmacokinetics - AUC for THC and THC metabolites	Whole blood concentrations of THC, 11-OH- THC, and THCCOOH will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis. The area under the curve (AUC) is calculated across all timepoints, minus the baseline. Characterizing these cannabinoids will allow for adequate control for individual differences in drug absorption and metabolism in statistical analyses and assist with interpretation of subjective and behavioral outcomes.	Up to 6 hours
Secondary	Pharmacokinetics - Breath Alcohol Concentration (BAC)	BAC will be measured using the Alco-Sensor IV. Measuring BAC is needed to confirm that participants reached the targeted BAC for a given session and to confirm adherence to pre-session alcohol abstinence requirements.	Up to 6 hours