Alcohol Drinking Clinical Trial
Official title:
Effect of Nutritional Ketosis on Alcohol Metabolism
The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after consuming about 4-5 alcohol beverages. The labs visits will use magnetic resonance imaging (MRI) scans to study the brain, measuring levels of nicotinamide adenine dinucleotide (NAD), lactate, neurotransmitters glutamate, and Gamma-aminobutyric acid (GABA).
The research study is being conducted to better understand the effects of ketosis on brain functioning and the acute effects of alcohol. Healthy participants will undergo three randomly assigned dietary interventions, each lasting three days, followed by a study lab visit day on day 4. The three interventions are: (1) Eat a ketogenic diet for 3 days, (2) eat a control diet for 3 days with a ketone supplement drink, and (3) eat a control diet for 3 days. The dietary interventions will be spaced 1 week apart. The ketone supplement drink (Kenetik, Vitanav inc, Washington DC) is a dietary supplement that has been extensively studied in humans and is designated by the FDA as Generally Recognized as Safe (GRAS). Its use in this study is experimental. On the day of the 3 labs visits days, magnetic resonance imaging (MRI) will be used to study the brain. Specifically, levels of nicotinamide adenine dinucleotide (NAD) (a coenzyme that is important for energy metabolism), lactate (a metabolite produced during energy metabolism), and neurotransmitters glutamate and GABA. Following the scans, participants will be provided a dose of alcohol that will elevate participants breath alcohol levels to approximately 0.08% to measure the acute effects of alcohol. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05414344 -
A Brief Intervention for Alcohol Users With Interpersonal Trauma
|
N/A | |
| Completed |
NCT05521906 -
Evaluation of PRYSHM for LGBTQIA2S+ Youth
|
N/A | |
| Not yet recruiting |
NCT04786587 -
Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
|
||
| Withdrawn |
NCT04659278 -
Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use
|
N/A | |
| Not yet recruiting |
NCT03632408 -
Hangover and Residual Zopiclone Effect on Spatial Perception
|
Phase 1 | |
| Completed |
NCT02718508 -
An e-Parenting Skills Intervention to Decrease Injured Adolescents' Alcohol Use
|
N/A | |
| Active, not recruiting |
NCT02629679 -
Sports, Education and Consumption of Substances in Adolescents
|
N/A | |
| Completed |
NCT02945371 -
Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life
|
N/A | |
| Completed |
NCT01553136 -
Varenicline Treatment of Alcohol Dependence in Smokers
|
Phase 2 | |
| Completed |
NCT01442753 -
Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth
|
N/A | |
| Completed |
NCT01081119 -
Brief Voluntary Alcohol and Drug Intervention for Middle School Youth
|
Phase 2 | |
| Completed |
NCT04510116 -
Adults In The Making Prevention Trial
|
N/A | |
| Completed |
NCT00289965 -
Substance Use Risk Education (SURE) Project
|
Phase 2 | |
| Completed |
NCT00506753 -
Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail
|
N/A | |
| Recruiting |
NCT05288790 -
Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
|
Phase 2 | |
| Recruiting |
NCT05620849 -
Young Adult Education on Alcohol & Health
|
N/A | |
| Recruiting |
NCT04054466 -
Nursing Counseling to the Change of Behavior of Alcohol Consumption in Patients in HAART
|
N/A | |
| Recruiting |
NCT03588754 -
Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
|
Phase 2 | |
| Recruiting |
NCT06074341 -
TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study
|
N/A | |
| Terminated |
NCT04596267 -
Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers
|
Phase 1 |