Alcohol Drinking Clinical Trial
Official title:
NMDA Antagonist Efficacy in Reducing Human Alcohol Consumption: Impact of Family History
Verified date | March 2020 |
Source | Yale University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to evaluate the effects of the study medication, memantine (placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. We hypothesize that memantine will reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period. We will also evaluate the influence of family history of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.
Status | Completed |
Enrollment | 111 |
Est. completion date | August 2011 |
Est. primary completion date | May 2011 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 21 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Ages 21-50 - Able to read English at 6th grade level or higher and to complete study evaluations - Regular alcohol drinker Exclusion Criteria: - Individuals who are seeking alcohol treatment - Medical conditions that would contraindicate the use of memantine - Regular use of other substances |
Country | Name | City | State |
---|---|---|---|
United States | CMHC | New Haven | Connecticut |
Lead Sponsor | Collaborator |
---|---|
Yale University | National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Drinks Consumed on Day 7 | Day 7 | ||
Primary | Baseline-adjusted Craving (YCS) | Craving for alcohol based on Yale Craving Scale, scores ranging from 0-112 mm on a visual analog scale, with higher measurements indicating higher craving. The baseline-adjusted craving is change score from baseline at Day 7. | Day 7 | |
Secondary | Stimulation Responses to Alcohol | Brief Biphasic Alcohol Effects Scale-Stimulation subscale, measuring stimulation effects of alcohol on Day 7, 6 items, 11-point rating scale from 0=Not at All to 10=Extremely, total scores ranging from 0 - 30, with higher measurements indicating higher stimulation. | Day 7 | |
Secondary | Sedation Responses to Alcohol | Brief Biphasic Alcohol Effects Scale-Sedation subscale, measuring sedation effects of alcohol on Day 7, 6 items, 11-point rating scale from 0=Not at All to 10=Extremely, total scores ranging from 0 - 30, with higher measurements indicating higher sedation. | Day 7 |
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