Alcohol Drinking Clinical Trial
Verified date | July 2005 |
Source | Piyavate Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Thailand: Food and Drug Administration |
Study type | Interventional |
Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a
great role in homeostasis, especially as a potent anti-oxidant.
As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and
excretes in urine as mercapturic acid.
In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on
blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing
effect.
The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a
correlation with hangover symptoms. This study is designed to find this correlation using
blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the
Slutske et al study.
Status | Completed |
Enrollment | 100 |
Est. completion date | August 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 20 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Healthy - Males 20-40 years old - No allergies to alcohol Exclusion Criteria: - Chronic disease - Increase in hepatic enzyme SGPT - Impending danger |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Thailand | Piyavate Hospital | Bangkok |
Lead Sponsor | Collaborator |
---|---|
Piyavate Hospital | T.C Union Global Plc. |
Thailand,
L. Casciani et al.,Effect of GSH on hepatic triglyceride levels at different times after ethanol intoxification IRSC Med.Sci.,vol.14,158(1986)
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