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NCT01515631 Clinical Trial

Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review

Alagille Syndrome Clinical Trial

Official title:
Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01515631
Other study ID # AG9031
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 2007
Est. completion date February 2018

Study information
Verified date September 2018
Source Stanford University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Patients who have Alagille Syndrome (AGS) also frequently have blockages (or "stenoses") of their pulmonary arteries. Little is known about the degree or variability of these stenoses, or the effect of this disease on the right ventricle (the chamber of the heart which pumps blood to the lungs). This study will first quantify and describe pulmonary artery stenosis in patients with Alagille Syndrome. The study will also assess the effect of these stenoses on the right ventricle. The investigators hope to learn the degree and characteristics of pulmonary artery stenosis in Alagille Syndrome. The investigators also hope to learn the effect of this pulmonary artery stenosis on the right ventricle in patients with Alagille Syndrome. This information is critical in the management of patients with Alagille syndrome, as there is currently no data to guide clinicians on the management of pulmonary artery stenosis. Furthermore, the information from this study may help physicians manage pulmonary artery stenosis in other patients as well.

Description:

The investigators hope to learn the degree and characteristics of pulmonary artery stenosis in Alagille Syndrome. We also hope to learn the effect of this pulmonary artery stenosis on the right ventricle in patients with Alagille Syndrome. This information is critical in the management of patients with Alagille syndrome, as there is currently no data to guide clinicians on the management of pulmonary artery stenosis. Furthermore, the information from this study may help physicians manage pulmonary artery stenosis in other patients as well. For the third aim, we hope to learn about the different blood vessel abnormalities in the brain, and which abnormalities are most likely to lead to stroke.

Recruitment information / eligibility
Status Completed
Enrollment 25
Est. completion date February 2018
Est. primary completion date February 2018
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Diagnosis of Alagille Syndrome

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Lucile Packard Children's Hospital at Stanford Palo Alto California

Sponsors (1)
Lead Sponsor Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Assessment of PA in Alagille Patient Open
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