AJCC Stage II and III Clinical Trial
Official title:
Phase II Study of Preoperative Radiotherapy for Sarcomas of the Extremities With Intensity-Modulation, Image-Guidance, Small Safety-margins and Brachytherapy Conditioned by Resection Margin
RATIONALE: Modern radiotherapy techniques in a neoadjuvant setting have the potential to
minimize morbidity and maximize efficacy. An additional boost dose can be provided locally by
HDR-brachytherapy in patients with positive margins after tumor resection.
PURPOSE: This phase II trial is studying the safety and efficacy of a combination of modern
radiotherapy elements applied to the tumor and small volumes of surrounding normal tissue
(IMRT, IGRT; brachytherapy in case of positive resection margin) and see how well it works in
treating patients with High-Risk Soft Tissue Sarcoma of the Extremities.
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