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Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS

AIDS Dementia Complex Clinical Trial

Official title:
Ferumoxytol-enhanced Imaging and Quantitative Susceptibility Mapping in neuroAIDS

Clinical Trial Summary

This project will investigate the ability of a novel MRI contrast agent to identify and quantitate ongoing monocyte/macrophage (M/MΦ)-mediated inflammation in the brains of HIV-infected individuals.

Clinical Trial Description

HIV-associated neurocognitive disorders (HAND) continue to be prevalent despite effective combination antiretroviral therapy (cART) and have a significant impact on morbidity and quality of life. Monocytes/macrophages (M/MΦ) are believed to play a critical role in the pathogenesis of HAND. Neuroimaging HIV research has not focused on assessing M/MΦ-mediated inflammation in the brain. Currently, no neuroimaging modality exists that can define the extent of active inflammation due to M/MΦ in HAND either as a clinical diagnostic tool or to assist in defining objective improvement in clinical trials addressing HAND. Ferumoxytol is an ultra-small iron oxide MRI contrast agent avidly taken up by circulating M/MΦ. The investigators hypothesize that ferumoxytol-based imaging can identify ongoing inflammation due to perivascular M/MΦ which is believed to represent a key pathologic correlate of HAND. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02678767
Study type Interventional
Source University of Hawaii
Contact
Status Completed
Phase Phase 2
Start date February 2015
Completion date September 2017
View Details
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