Aging Clinical Trial
— TRPOfficial title:
Transient Receptor Potential Channels in Human Skin
Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.
Status | Not yet recruiting |
Enrollment | 45 |
Est. completion date | December 31, 2026 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - 18-85 years old. - Women will not be pregnant and/or breastfeeding. Exclusion Criteria: - Currently pregnant or breastfeeding - Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime) - Known skin allergies or current rash, skin disease, disorders of pigmentation - Diabetes - Body mass index >35kg*m-2 - Using calcium channel blockers - Raynaud's syndrome - Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive - Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin |
Country | Name | City | State |
---|---|---|---|
United States | Noll Laboratory | University Park | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Penn State University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Skin blood flow during slow local heating | Laser doppler flowmeter to measure skin blood flow during a slow local heating of the skin | 75 minutes | |
Primary | Somatosensory perception | heat and cold perception using a visual analog scale | every 5 minutes for 120 minues | |
Primary | algometer measurement | pain pressure thresholds | every 30 minutes for 120 minutes |
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