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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06374069
Other study ID # NL81887.058.23
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 11, 2023
Est. completion date December 2026

Study information

Verified date April 2024
Source Leiden University Medical Center
Contact (Eline) P. Slagboom, Prof. dr.
Phone +31(0)71 5269 730
Email p.slagboom@lumc.nl
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity. The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.


Recruitment information / eligibility

Status Recruiting
Enrollment 600
Est. completion date December 2026
Est. primary completion date December 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 75 Years and older
Eligibility Inclusion Criteria: - Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity - Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity Exclusion Criteria: -

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
Netherlands Leiden University Medical Center Leiden South Holland

Sponsors (3)

Lead Sponsor Collaborator
Leiden University Medical Center Jacobijn Gussekloo, Prof. dr., Simon P. Mooijaart, Prof. dr.

Country where clinical trial is conducted

Netherlands, 

Outcome

Type Measure Description Time frame Safety issue
Primary Identifying the genetic variants of Familial Longevity To identify gene variants associated with healthy aging and protection from (multi)morbidity through study completion, an average of 2 years
Secondary Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component through study completion, an average of 2 years
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