Aging Clinical Trial
— BrainActOfficial title:
Compensatory Brain Activity in Older Adults. The Search for the Electrophysiological Indicators of Cognitive Processes Involved in This Activity, and Its Possible Changes Induced by Working Memory Training
Verified date | January 2024 |
Source | Kazimierz Wielki University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults. First, in the studies that have been conducted so far the compensatory brain activity in older adults was investigated primarily with the use of the functional magnetic resonance (fMRI) or positon emission tomography (PET). In order to identify compensatory activity in our study we will use electroencephalographic markers (observable in EEG). It will allow to confirm the assumptions about compensatory brain activity relying on new data, as in EEG research the brain markers of the same cognitive processes are different from those used in fMRI and PET research. What is more, in the studies conducted so far brain activity in older adults was only registered and interpreted, whereas the present study additionally adds the training component. The aim of our study is to see if it is possible to influence the compensatory brain activity through cognitive functions training, relying on working memory training. Theoretically, such a training should optimize brain activity in older adults, namely evoke compensatory brain activity during difficult tasks in order to make them easier, whereas in the case of easy tasks it should lead to the disappearance of the need to trigger compensatory activity. This assumption will be verified in an experimental setting. The participants will be divided into six groups: two experimental (the groups of young and old adults), and by analogy two active control groups and two passive (no-contact) control groups. The experiment was designed in the following way: (1) All groups will be subjected to pre-test measurements that will be EEG registration during a cognitive task execution at different difficulty levels; (2) Experimental groups will undergo working memory training. Over the period of 4 weeks participants in the experimental groups will take part in 12 training sessions. In the active control groups instead of the n-back training the practice of tasks which do not involve working memory will be introduced. Participants of the passive control groups will be awaiting post-test (no-contact control); (3) In all groups post-test measurements will be administered analogically to the pre-test measurements in order to assess changes in cognitive tasks performance and related brain activity.
Status | Completed |
Enrollment | 117 |
Est. completion date | January 24, 2024 |
Est. primary completion date | January 24, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 75 Years |
Eligibility | Inclusion Criteria: - Age: belonging to one of the age groups - older adults (60-75 years old) or young adults (20-35 years old). The 60-75 age group limits the influence of the advance of various age-related changes, and at the same time, this group is classified as early late-adulthood. The 20-35 group, on the other hand, falls within early adulthood (Sugarman, 2001); - No history of mental illness; - No history of neurological disorders, including neurodegenerative diseases, or severe head injuries. - Normal or corrected-to-normal vision; - Intellectual norm; - No dementia symptoms (in old adults); - No visible abnormal brain activity in EEG (verifiable only in the pre-test); - Signing an informed consent to participate in the study (after familiarizing oneself with the aim of the study and the conditions of participation, as well as having received satisfactory answers to all questions). |
Country | Name | City | State |
---|---|---|---|
Poland | Kazimierz Wielki University, Faculty of Psychology | Bydgoszcz | Polska |
Lead Sponsor | Collaborator |
---|---|
Kazimierz Wielki University | John Paul II Catholic University of Lublin, Poland, National Science Centre, Poland |
Poland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | M.I.N.I. Screen 7.0.2 | A structured diagnostic interview - Mini International Neuropsychiatric Interview - The M.I.N.I. Screen 7.0.2. - to screen for the presence of psychiatric disorders | On the first day of participation in the study, successively for the following participants over 3 years | |
Other | Structured interview | • A structured interview, constructed for the purpose of the study: to gather information about age, neurodegenerative diseases, severe head injuries, vision defects | On the first day of participation in the study, successively for the following participants over 3 years | |
Other | MMSE | Mini Mental State Examination - MMSE: to screen for dementia in older adults; the minimum and maximum values: 0-30, higher scores mean a better outcome | On the 1st day of participation in the study of each older adult, successively for the following participants over 3 years | |
Other | ACE III | • The Addenbrooke's Cognitive Examination III - ACE III: to screen for the presence of cognitive impairment in older adults; minimum and maximum values: 0-100, higher scores mean a better outcome | On the 1st day of participation in the study of each older adult, successively for the following participants over 3 years | |
Primary | Change EEG power in theta, alpha and gamma bands (n-back task) | The neural brain activity accompanying cognitive engagement during the n-back task execution. EEG data will be obtained from 32 Ag/AgCl electrodes (left: Fp1, AF3, F3, F7, FC1, FC5, C3, CP1, CP5, F7, P3, P7, PO3, O1; right: Fp2, AF4, F4, F8, FC2, FC6, C4, CP2, CP6, F8, P4, P8, PO4, O2; midline: Fz, Cz, Pz, Oz) placed in accordance with the 10-20 international system and referenced to the right and left earlobes. | change from baseline at 4 weeks | |
Primary | Change n-back task | Accuracy and reaction times in the n-back task indicated by the senstitivity index | change from baseline at 4 weeks | |
Primary | Change in EEG power in theta, alpha and gamma bands (GoNoGo task) | The neural brain activity accompanying cognitive engagement during the GoNoGo task execution. EEG data will be obtained from 32 Ag/AgCl electrodes (left: Fp1, AF3, F3, F7, FC1, FC5, C3, CP1, CP5, F7, P3, P7, PO3, O1; right: Fp2, AF4, F4, F8, FC2, FC6, C4, CP2, CP6, F8, P4, P8, PO4, O2; midline: Fz, Cz, Pz, Oz) placed in accordance with the 10-20 international system and referenced to the right and left earlobes. | change from baseline at 4 weeks | |
Primary | Change in GoNoGo task | Accuracy and reaction times in the GoNoGo task. | change from baseline at 4 weeks | |
Primary | Change in EEG power in theta, alpha and gamma bands (Stroop task) | The neural brain activity accompanying cognitive engagement during the Stroop task execution. EEG data will be obtained from 32 Ag/AgCl electrodes (left: Fp1, AF3, F3, F7, FC1, FC5, C3, CP1, CP5, F7, P3, P7, PO3, O1; right: Fp2, AF4, F4, F8, FC2, FC6, C4, CP2, CP6, F8, P4, P8, PO4, O2; midline: Fz, Cz, Pz, Oz) placed in accordance with the 10-20 international system and referenced to the right and left earlobes. | change from baseline at 4 weeks | |
Primary | Change in Stroop task | Accuracy and reaction times in the Stroop task | change from baseline at 4 weeks | |
Primary | Change in OSpan task | Accuracy in the OSpan task | change from baseline at 4 weeks | |
Secondary | Change in Digit Span | The Digit Span Subtest from the Wechsler Adult Intelligence Scale - WAIS-R (PL) | change from baseline at 4 weeks | |
Secondary | Change in Digit-Symbol | The Digit-Symbol Coding Subtest from the Wechsler Adult Intelligence Scale - WAIS-R (PL) | change from baseline at 4 weeks | |
Secondary | Change in Raven's SPM | Raven's Standard Progressive Matrices: Classic form in Polish standardisation / Parallel form n Polish standardization. minimum and maximum values (raw score): 0-60, higher scores mean a better outcome | change from baseline at 4 weeks |
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