Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study

Aging Clinical Trial

Official title:

Cardiorespiratory Fitness and the Apolipoprotein E (ApoE) Genotype and Its Interaction With Cognitive Functions and Cognitive Decline in Late-Middle-Aged Older Adults: A Prospective Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05652140
• Other study ID #: PACNL_APOE_PROSPECTIVE
• Status: Completed
• Start date: July 1, 2018
• Est. completion date: May 1, 2021

Study information

• Verified date: February 2023
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.

Description:

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve:

1. An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults.

2. The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms.

3. An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 160
• Est. completion date: May 1, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 70 Years

Eligibility

Inclusion Criteria:

• right handed

• no history of cardiorespiratory disease

• normal or corrected-to-normal vision based on the 20/20 standard

• no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire

Exclusion Criteria:

• the scores of Mini-Mental Status Examination (MMSE) < 25 and cognitively intact upon study entry

• history of psychiatric or neurological diseases

• color-blindness

Related Conditions & MeSH terms

• Aging
• Cognitive Change

Intervention

Other:
• Data collections
Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

Locations

Country	Name	City	State
Taiwan	Department of Physical Education and Sport Sciences, National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in inhibitory performance: Stroop task	Inhibitory performance was assessed using the computerized Stroop task at the baseline and at the follow-up assessments. Changes in inhibitory performance from Baseline to the Follow-Up Stages were assessed.	30 minutes each at the Baseline and the Follow-Up Stages.
Primary	Changes in higher order executive performance: Tower of London Test	Higher order executive performance was assessed using the Tower of London Test at the baseline and at the follow-up assessments. Changes in higher order executive performance from Baseline to the Follow-Up Stages were assessed.	25 minutes each at the Baseline and the Follow-Up Stages.
Primary	Changes in neuroelectrical activities	The neuroelectrical activities during the Stroop task were recorded and analyzed using the Neuroscan system. Changes in the neuroelectrical activities from Baseline to the Follow-Up Stages were assessed.	30 minutes each at the Baseline and the Follow-Up Stages.
Secondary	ApoE genotype	Based on the genetic biomarkers (rs429358 and rs7412), participants' ApoE genotype was determined.	5 minutes at the Baseline Stage.
Secondary	Physical fitness measurements: Changes in aerobic fitness	Participants' aerobic fitness was estimated using the submaximal cycle ergometer test at the baseline and at the follow-up assessments. Changes in aerobic fitness from Baseline to the Follow-Up Stages were assessed.	20 minutes each at the Baseline and the Follow-Up Stages.