Effects of Quercetin on Metabolic Health

Aging Clinical Trial

Official title:

Evaluation of a Computational Model That Predicts the Effects of Quercetin on Metabolic Health Using Biological Age and Other Lipid-related Blood Metrics

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT05297032
• Other study ID #: TRIn-QP01
• Status: Terminated
• Phase: N/A
• Start date: March 24, 2022
• Est. completion date: September 2, 2022

Study information

• Verified date: January 2023
• Source: Thorne Research Inc.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Quercetin is a natural flavonoid compound widely found in vegetables, fruits, and nuts. It has a long history of use as a dietary supplement. This study aims to assess results from a computational model suggesting that quercetin may offer novel benefits to metabolic health. Participants will take quercetin (as Quercetin Phytosome, a proprietary formulation with enhanced absorption properties) for 90 days while keeping lifestyle habits consistent throughout to estimate net effects of quercetin as much as possible. Blood samples will be collected at the beginning and end of the study to assess the effects of quercetin supplementation on metabolic health metrics such as LDL cholesterol, blood sugar, liver, kidney and immune function and calculated metabolic age. In addition, questionnaires will be completed to ensure compliance with study requirements and assess potential quercetin benefits in the participants' quality of life. This work will provide a proof-of-concept from a computational model of nutraceutical compounds and proposes a new application of quercetin in support of healthy human metabolism.

Description:

Following intake and enrollment steps, including providing consent, and approximately one week before other study activities begin, participants will submit an online questionnaire to collect baseline data about lifestyle factors such as diet, exercise, sleep, stress, and general quality of life. During this period they will also receive the study supplement and schedule their first blood draw at a local-to-them Quest Diagnostics facility. Participants will begin taking the study supplement on the day after their first blood draw. Study dosing consists of one capsule of Quercetin Phytosome (Thorne Research, Inc.; 250 mg) taken three times per day with meals for 90 days. Approximately one week after beginning to take study doses, and bi-weekly thereafter, participants will complete an online questionnaire to monitor lifestyle and quality of life factors. The final questionnaire will be completed on the day of or the day after the last study dose is taken. The day after the last study dose, participants will complete a second blood draw at Quest Diagnostics.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 5
• Est. completion date: September 2, 2022
• Est. primary completion date: August 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

• Age: 20-70 years

• Self-report that, within the past 6 months, a medical professional has informed them of, or a blood test result has shown high-healthy Low Density Lipoprotein (LDL) levels (preferred range, if known: 130-159 mg/dL)

AND 2 or more of the following 4 (values are preferred, if known):

• Low-healthy fasting High Density Lipoprotein (HDL < 50 mg/dL)

• High-healthy fasting Triglycerides (TG 150-199 mg/dL)

• High-healthy fasting Blood Sugar (Glucose 100-126 mg/dL)

• Waist Circumference > 40 in for men or > 35 in for women (this may be self-measured)

Also

• Willing and able to travel to a Quest location for both blood draws

• Willing and able to fast (except water) for 12 hours prior to each blood draw

• Willing and able to comply with the study schedule (+/- 2 days)

• Willing and able to complete online questionnaires

• Willing and able to check email for study-related messages regularly (daily) and to use email as the primary means of communication for non-emergency study-related contact with the study team

• Informed consent to participate in the study discussed and signed

• Willing and able to avoid making changes to diet, sleep, stress, exercise, and other lifestyle factors that may influence the study metrics

• Willing and able to avoid use of the following supplements during the study:

• Quercetin, Berberine, Red Yeast Rice, Fish Oil, Bergamot Juice Extract, Pantethine, Vitamin D3 dosing over 5,000IU daily, Pterostilbene, Aged Garlic, Phytosterols, Niacin (crystalline/acid, not niacinamide), Meriva/curcumin/turmeric

Exclusion Criteria:

• Individuals who live in NY, NJ, RI, SD, ND, HI, or MD (due to lack of availability of WellnessFX or Quest services)

• Individuals who are currently taking any lipid-lowering medications (including statins) or have taken them within the past 6 months.

• Individuals who are currently taking or have taken any lipid-lowering supplements (including quercetin) consistently in the past 4 weeks. Excluded supplements are products that contain:

o Berberine, Red Yeast Rice, Fish Oil, Bergamot Juice Extract, Pantethine, Vitamin D3 dosing over 5,000IU daily, Pterostilbene, Aged Garlic, Phytosterols, Niacin (crystalline/acid, not niacinamide), Meriva/curcumin/turmeric

• Diagnosed with metabolic syndrome

• Being treated for hypertension

• Known allergy or sensitivity to any components of the trial's nutritional supplement

• Myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, or stent within five years

• Known clinical coronary heart disease symptoms

• Known clinical angina

• History of cerebrovascular accident

• Creatinine > 2.5 mg/dL

• Chronic liver disease with AST, ALT, or alkaline phosphatase over 1.5 times normal

• Known cancer within two years

• Clinical congestive heart failure (systolic or diastolic CHF)

• Type 1 or type 2 diabetes mellitus

• Habitual drinking (cutoff at PI discretion using the following guidelines: 8 or more drinks a week) or being a current smoker/vaping

• Pregnant or nursing

• Women of child-bearing age not using an approved contraceptive

• Planned major surgery during the study (1 week before first blood draw and during the 90-day supplementation)

Related Conditions & MeSH terms

• Aging
• Lipid Metabolism

Intervention

Dietary Supplement:
• Quercetin Phytosome
All participants will ingest 1 capsule of Quercetin Phytosome (250 mg) three times daily with meals for 90 days.

Locations

Country	Name	City	State
United States	This is a remote study - participants will find a commercial lab location near them.	Summerville	South Carolina

Sponsors (2)

Lead Sponsor	Collaborator
Thorne Research Inc.	Indena S.p.A

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Biological Age score from before (day 0) to after (day 90) supplementation	Quantitative changes before and after intervention in calculated metrics of biological age.; These metrics are calculated by applying the Klemera-Doubal algorithm to a proprietary set of clinical measures. (Scale for each metric: 0-120) (ref: https://academic.oup.com/biomedgerontology/article/74/Supplement_1/S52/5625183?login=true)	90 days
Primary	Change in Apolipoprotein B from before (day 0) to after (day 90) supplementation	Quantitative changes before and after intervention in Apolipoprotein B test (Quest Diagnostics 91726) (Scale: mg/dL)	90 days
Primary	Change in Lipoprotein Fractions from before (day 0) to after (day 90) supplementation	Quantitative changes before and after intervention in Lipoprotein Fractionation, Ion Mobility test (Quest Diagnostics 91604) (Scale: particle number)	90 days
Primary	Quality of Life scale changes from before (day 0) to after (day 90) supplementation	Quantitative changes in The Quality of Life Scale (Scale: 1-100 as determined by ref: http://www.jstor.org/stable/4034400)	90 days
Secondary	Lifestyle changes from before (day 0) to after (day 90) supplementation	Quantitative changes among any time points in metrics of lifestyle measured by questionnaire.; Questionnaire metrics and scales: Stress: 1-10 (little or none:1, extreme:10) Exercise: 1-10 (little or none:1, extreme:10) Diet: 1-10 (very unhealthy:1, very healthy:10) Sleep: 1-10 (very poor:1, excellent:10)	90 days