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NCT04926987 Clinical Trial

The Research of Human Cortex Cell Atlas

Aging Clinical Trial

Official title:
The Research of Human Cortex Cell Atlas

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04926987
Other study ID # 2020-030
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 1, 2020
Est. completion date December 30, 2022

Study information
Verified date June 2021
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact Jianmin Zhang, M.D
Phone 86-13805722695
Email zjm135@zju.edu.cn
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In this study, the single-cell transcriptome sequencing technology was used to study the transcriptome differences at the single-cell level in normal human brain, aging human brain, and epileptic brain.

Description:

The human brain has about 100 billion cells and makes up neural networks.The abnormal activity of neurons can affect the operation of neural networks, leading to neurological diseases.With the coming of the age of global population aging, neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's have become an increasing burden on human health. Cells are the basic unit of brain. Understanding the mechanism of brain activities includes not only the mechanism of neural network, but also the self-regulation of its basic unit, that is, the regulation of gene expression based on brain activity.The abnormal expression and regulation of genes lead to the abnormal activities of the nervous system.Therefore, studying the regulation mechanism of gene expression at the cellular level is an important way to research brain diseases.The recent development of single-cell RNA-sequencing technology provides a possibility to understand the functioning mechanism of the brain at the cellular level.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date December 30, 2022
Est. primary completion date December 30, 2022
Accepts healthy volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Craniocerebral injury patients needing operative treatment - Treatment-resistant epilepsy patients needing resection surgery Exclusion Criteria: - Vital signs unstable - Pregnancy - Tumor - Incomplete medical history, imaging and clinical diagnosis

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• brain tissue single-cell sequencing
Using single-cell sequencing to study the brain tissue single-cell transcriptome difference in aging, epilepsy, and mental disorders

Locations
Country Name City State
China 2ndAffiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang

Sponsors (1)
Lead Sponsor Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary single-cell RNA sequencing single-cell RNA sequencing resultes of brain sample 1 Day of surgery
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