| Eligibility |
Inclusion Criteria:
1. Men and women aged = 18 years.
2. Chinese ethnicity.
3. Subjects who wanting to correct his/her nasolabial folds
4. Subjects with moderate to severe nasolabial folds (attaining grade 3 on both side or 4
on both side) in the WSRS of nasolabial fold, per assessment of the Blinded Evaluator.
5. Subjects willing to abstain from other facial plastic surgical or cosmetic procedures
during the study period.
6. Subjects with realistic expectations who can understand and comply with the
instructions and all visit schedule.
7. Women of childbearing potential (WOCBP) who agree contraception during the study
period.
8. Subjects who voluntarily decided the participation of the study and signed the
informed consent.
9. Being able to stand mild pain.
Exclusion Criteria:
1. Subjects who are contraindicated to augmentation with HA fillers
2. Subjects who had a history of keloid formation or hypertrophic scar
3. Subjects presenting a scar or skin disorder (i.e. active dermal disease [facial
psoriasis, eczema, rosacea, perioral dermatitis, acne, herpes, etc], inflammation or
an unhealed wound) below the level of the lower orbital rim that may confound the
study evaluation
4. Has ever received semi-permanent fillers or permanent facial implants (eg, calcium
hydroxyapatite, poly-L-lactic acid, polymethylmethacrylate, silicone, expanded
polytetrafluoroethylene) anywhere below the inferior orbital rim, or is planning to be
implanted with any of these products at any time during the study
5. Has undergone temporary dermal filler treatment (e.g., hyaluronic acid or collagen)
below the inferior orbital rim within 12 months before enrollment or is planning to
undergo such treatment during the study
6. Has undergone facial tissue augmentation with fat injections, botulinum toxin
injections, mesotherapy, or cosmetic facial procedures (eg, facial liposuction,
aesthetic surgery, face-lift, photomodulation, intense pulsed light, radio frequency,
dermabrasion, laser or chemical peel, or other ablative procedures) below the inferior
orbital rim within 6 months before enrollment or is planning to undergo any such
treatment during the study
7. Subjects who has any history of severe multiple allergies or an allergy resulting in
anaphylaxis, or an allergy to hyaluronic acid and/or one of the ingredients of the
study products
8. Subject is pregnant or planning to be pregnant during the study period or lactating.
Women of childbearing potential who have a positive pregnancy test result during
screening. Women of childbearing potential who are unwilling to use effective birth
control measures during the full course of the study
9. Subject suffering from a serious or progressive disease, which, in the Investigator's
judgment, put the subject at undue risk for participation in this clinical trial (i.e.
cancer or pre-cancer, immunocompromised, uncontrolled diabetes, epilepsy, severe
cardio-cerebrovascular disease(s) (i.e. stroke, idiopathic aortic stenosis, aneurysm,
hypertrophic obstructive cardiomyopathy, ischaemic heart disease, tachyarrhythmias,
severe heart failure [classified as NYHA III-IV], etc), , etc.)
10. Subject having a history of cancer within 5 years
11. Subjects who received oral surgery (eg. tooth extraction, orthodontia or implantation)
within 6 weeks before enrollment or is planning to undergo any of these procedures
during the study
12. Subject has history or active autoimmune disease (e.g. inflammatory bowel disease),
active or history of connective tissue disease (rheumatoid arthritis, scleroderma, and
systemic lupus erythematosus)
13. Subjects with current or a history of hemorrhagic diseases
14. Subject who received chemotherapy, immunosuppressive agents, immunomodulatory therapy
(e.g. monoclonal antibodies), systemic corticosteroids within 3 months (inhaled
corticoids are allowed).
15. Subjects unlikely to achieve a meaningful aesthetic result with the prescribed dosage
regimen of the study product per Investigator's judgement
16. Subjects who participated in other clinical trial within 30 days or who is in an
exclusion period of one.
17. Subjects with uncontrolled hypertension (systolic blood pressure above 160mmHg or
diastolic blood pressure above 100 mmHg at resting status), and/or significant liver
(serum ALT or AST =2X the upper limit of the reference range), kidney (BUN, Urea or
Cr=1.5X the upper limit of the reference range), and/or blood coagulation (PT, or
APTT, or INR> 20% of the reference range) disorders per judgement of the Investigator.
18. Current or a history of alcoholism, drug abuse, or drug dependence.
19. Subject who had been deprived of their freedom by administrative or legal decision or
who is under guardianship
20. Subject with a past history of streptococcal disease (manifested by recurrent sore
throat or acute rheumatic fever) or with an active infection to streptococcus
21. Has facial hair (e.g., beards, sideburns, etc.), piercing or tattoo in the area to be
treated that would interfere with investigation assessments and create inconsistency
in required investigation photography during the study period
22. Personnel of the study department, close relatives of the study department personnel
(i.e. parents, children, siblings, or spouse), employees, or close relatives of
employees at the Sponsor or CRO company.
23. Other conditions the Investigator considers inappropriate for enrollment
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