Effects of tDCS on Social Cognition in Aging

Aging Clinical Trial

— SoCoStim  

Official title:

Effects of tDCS on Visual Perspective Taking and Emotion Recognition in Healthy Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04633499
• Other study ID #: SoCoStim
• Status: Completed
• Phase: N/A
• Start date: August 1, 2020
• Est. completion date: May 31, 2022

Study information

• Verified date: June 2022
• Source: University Medicine Greifswald
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to explore the effect of transcranial direct current stimulation (tDCS) on either the right tempo-parietal junction (rTPJ) or the dorsomedial prefrontal cortex (dmPFC) in healthy older adults (replication in a different sample of a study by Martin et al., 2020).

Description:

Humans are fundamentally social animals. The ability to operate within large social networks requires considerable cognitive capacity, often referred to as social cognition. One social cognitive process thought to involve embodied and nonembodied processes is perspective-taking. Recently, the right temporoparietal junction (rTPJ) has been suggested as a key hub for embodied processing relevant to social cognition. A study of Martin et al. (2020) could further provide causal evidence that the right temporoparietal junction is involved specifically in the embodied component of perspective-taking. Specifically, HD-tDCS (high-definition transcranial direct current stimulation) to the right temporoparietal junction, but not another hub of the social brain (dorsomedial PFC), increased the effect of body position during perspective-taking, but not tracking. As social cognition is affected by the aging process and decline of socio-cognitive abilities is a key feature of neurological diseases such as Alzheimer's or Parkinson's disease, the aim of the present study is to replicate the findings of Martin et al., (2020) in a sample of healthy older adults to better understand the modulation of socio-cognitive processes in older age.

The aim of the study is to explore the effect of transcranial direct current stimulation (tDCS) on either the right tempo-parietal junction (rTPJ) or the dorsomedial prefrontal cortex (dmPFC) in healthy older adults (replication in a different sample of a study by Martin et al., 2020). 60 healthy older adults and 30 younger participants (serving as a control group) will be tested in a Reading the Eyes in the Mind Task (RMET) and a Task of Visual Perspective Taking (VPT) , while stimulation either the rTPJ or the dmPFC with either active or sham tDCS (stimulation only in the group of older participants). In the RMET the expectation is that older participants have higher reaction times after correct answers under rTPJ tDCS. No stimulation effects of the dmPFC are expected. In the VPT older participants are expected to have a selective effect on body position (similar to the results of Martin et al., 2020) under rTPJ stimulation, but not dmPFC stimulation.

A further focus of the study is how functional and structural connectivity of the brain and individual differences measured with an MRI assessment influence with the success of the RMET and VPT paradigms in an explorative research question.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: May 31, 2022
• Est. primary completion date: May 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• healthy older (60 - 80 years) and younger (18 - 30 years) participants

• German as their main language or sufficient german skills to understand the experiment and the task

Exclusion Criteria:

• participants with neuropsychological or psychiatric disease that affect cognition.

• standard MRI exclusion criteria (e.g. pregnancy, metal implants)

• standard tDCS exclusion criteria (e.g. metal implants in the head)

Related Conditions & MeSH terms

• Aging
• Social Cognition

Intervention

Behavioral:
• Social Cognition Task
Two paradigms will be tested: visual perspective taking and reading the mind in the eyes.

Device:
• tDCS
tDCS either over the dmPFC or the rTPJ.

Locations

Country	Name	City	State
Germany	University Medicine Greifswald	Greifswald

Sponsors (1)

Lead Sponsor	Collaborator
University Medicine Greifswald

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Martin AK, Kessler K, Cooke S, Huang J, Meinzer M. The Right Temporoparietal Junction Is Causally Associated with Embodied Perspective-taking. J Neurosci. 2020 Apr 8;40(15):3089-3095. doi: 10.1523/JNEUROSCI.2637-19.2020. Epub 2020 Mar 4. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Response Time in milliseconds in Visual-Perspective Taking Paradigm (VPT) in the active tDCS.	The outcome in the VPT paradigm will be response time in milliseconds (for correct answers only).	at Day 1 or 7 (depends on randomization)
Primary	Response Time in milliseconds in Visual-Perspective Taking Paradigm (VPT) in the sham tDCS.	The outcome in the VPT paradigm will be response time in milliseconds (for correct answers only).	at Day 1 or 7 (depends on randomization)
Primary	Response Time in milliseconds in the Reading the mind in the eyes test (RMET) in the active tDCS.	Outcome in the RMET will be reaction times in milliseconds (of correct answers only) in either rTPJ or dmPFC stimulation in comparison to sham stimulation.	at Day 1 or 7 (depends on randomization)
Primary	Response Time in milliseconds in the Reading the mind in the eyes test (RMET) in the sham tDCS.	Outcome in the RMET will be reaction times in milliseconds (of correct answers only) in either rTPJ or dmPFC stimulation in comparison to sham stimulation.	at Day 1 or 7 (depends on randomization)
Secondary	Functional and structural connectivity (via MRI)	It will be investigated how functional and structural connectivity of the brain and individual differences measured with an MRI assessment influence with the success of the RMET and VPT paradigms in an explorative research question.Structural and functional connectivity will be assessed.	MRI Assessment takes places before participants are stimulated with tDCS at Baseline (Day 1).