Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed

Aging Clinical Trial

Official title:

Acute Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed and Decreases Conflict-related Neural Activity in Older Adults: A Crossover, Sham Control, Randomized Control Trial With REP

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04534374
• Other study ID #: 201807HM004
• Status: Completed
• Phase: N/A
• Start date: August 1, 2017
• Est. completion date: August 1, 2019

Study information

• Verified date: August 2020
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: August 1, 2019
• Est. primary completion date: August 1, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 50 Years to 65 Years

Eligibility

Inclusion Criteria:

1. male adults aged 50-65 years old

2. exercise = 150 minutes/week

3. normal or corrected-to-normal vision

4. right-handed

Exclusion Criteria:

1. dementia (MMSE = 24)

2. any medical condition listed on PARQ

3. depression (BDI-II score = 13)

4. any diagnostic cardiovascular, neurological and other chronic diseases

Related Conditions & MeSH terms

• Aging
• Cognitive Decline
• Cognitive Dysfunction

Intervention

Behavioral:
• Resistance exercise
Barbell back squat, press, and deadlift for three sets of five repetitions with the weight closest to 75% of their estimated 1 repetition max. The participants were instructed to execute the movement with moderate speed (2s eccentric, 2s concentric, no pause in between). The rest period between sets and exercise movements was two to three minutes.
• Stretching exercise (sham exercise)
Participants completed a passive stretching exercise session for a similar duration of time as the resistance exercise (˜ 30 min) as sham intervention, which included 15-20 stretching movements twice, holding each for 30 seconds as recommended by ACSM.

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change of Information processing speed between resistance and stretching exercises	Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.	5-30 minutes before and 10-35 minutes after each intervention.
Primary	Change of Inhibitory control between resistance and stretching exercises	Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.	5-30 minutes before and 10-35 minutes after each intervention.
Secondary	Change of Conflict-related neural activity between resistance and stretching exercises	N2b (event-related potential)	5-30 minutes before and 10-35 minutes after each intervention.
Secondary	Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises	P3 (event-related potential)	5-30 minutes before and 10-35 minutes after each intervention.