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NCT04430803 Clinical Trial

Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging

Aging Clinical Trial

— H2AGE  

Official title:
The Effects of Six-month Hydrogen-rich Water Intake on Molecular and Phenotypic Biomarkers of Aging in Men and Women Aged 70 Years and Over: a Randomized-controlled Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04430803
Other study ID # 281048E-HRW/2020
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 15, 2020
Est. completion date April 1, 2021

Study information
Verified date April 2021
Source University of Novi Sad, Faculty of Sport and Physical Education
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.

Recruitment information / eligibility
Status Completed
Enrollment 44
Est. completion date April 1, 2021
Est. primary completion date March 15, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 70 Years and older
Eligibility Inclusion Criteria: - Age > 70 years - Free of acute disorders Exclusion Criteria: - History of dietary supplement use during the past 4 weeks

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Hydrogen-rich water
A tablet that produces hydrogen dissolved in a glass of water
Other:
• Control Water
A glass of tap water

Locations
Country Name City State
Serbia FSPE Applied Bioenergetics Lab Novi Sad Vojvodina

Sponsors (1)
Lead Sponsor Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

References & Publications (1)

Xia X, Chen W, McDermott J, Han JJ. Molecular and phenotypic biomarkers of aging. F1000Res. 2017 Jun 9;6:860. doi: 10.12688/f1000research.10692.1. eCollection 2017. Review. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Change in TeloTAGGG Telomerase PCR activity in serum Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in DNA methylation Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in blood concentration of advanced glycation end product Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in lipid peroxidation Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in serum FGF21 Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in serum TET2 Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment) Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in facial wrinkling (0-100 scale; higher scores mean worse outcome) Baseline vs. 6 months Baseline vs. 6 months post-intervention
Secondary Change in maximal oxygen uptake estimated by step-in-place test Baseline vs. 6 months Baseline vs. 6 months post-intervention
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