Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging

Aging Clinical Trial

— H2AGE  

Official title:

The Effects of Six-month Hydrogen-rich Water Intake on Molecular and Phenotypic Biomarkers of Aging in Men and Women Aged 70 Years and Over: a Randomized-controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04430803
• Other study ID #: 281048E-HRW/2020
• Status: Completed
• Phase: N/A
• Start date: September 15, 2020
• Est. completion date: April 1, 2021

Study information

• Verified date: April 2021
• Source: University of Novi Sad, Faculty of Sport and Physical Education
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: April 1, 2021
• Est. primary completion date: March 15, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 70 Years and older

Eligibility

Inclusion Criteria:

• Age > 70 years

• Free of acute disorders

Exclusion Criteria:

• History of dietary supplement use during the past 4 weeks

Related Conditions & MeSH terms

• Aging

Intervention

Dietary Supplement:
• Hydrogen-rich water
A tablet that produces hydrogen dissolved in a glass of water

Other:
• Control Water
A glass of tap water

Locations

Country	Name	City	State
Serbia	FSPE Applied Bioenergetics Lab	Novi Sad	Vojvodina

Sponsors (1)

Lead Sponsor	Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

References & Publications (1)

Xia X, Chen W, McDermott J, Han JJ. Molecular and phenotypic biomarkers of aging. F1000Res. 2017 Jun 9;6:860. doi: 10.12688/f1000research.10692.1. eCollection 2017. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in TeloTAGGG Telomerase PCR activity in serum	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in DNA methylation	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in blood concentration of advanced glycation end product	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in lipid peroxidation	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in serum FGF21	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in serum TET2	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment)	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in facial wrinkling (0-100 scale; higher scores mean worse outcome)	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in maximal oxygen uptake estimated by step-in-place test	Baseline vs. 6 months	Baseline vs. 6 months post-intervention